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Mouse Anti-PCSK6 Recombinant Antibody (2D6) (CBMAB-P1100-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2D6
Antibody Isotype
IgG
Application
WB, IP, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
proprotein convertase subtilisin/kexin type 6
Introduction
PCSK6 is a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. The encoded protease is constitutively secreted into the extracellular matrix and expressed in many tissues, including neuroendocrine, liver, gut, and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. This gene is thought to play a role in tumor progression and left-right patterning.
Entrez Gene ID
5046
UniProt ID
P29122
Alternative Names
Proprotein Convertase Subtilisin/Kexin Type 6; Subtilisin-Like Proprotein Convertase 4; Subtilisin/Kexin-Like Protease PACE4; Paired Basic Amino Acid Cleaving System 4; Paired Basic Amino Acid Cleaving Enzyme 4; PACE4; SPC4;
Function
Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues.
Biological Process
Determination of left/right symmetryIEA:Ensembl
Glycoprotein metabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Nerve growth factor productionManual Assertion Based On ExperimentIDA:BHF-UCL
Peptide hormone processingManual Assertion Based On ExperimentIDA:BHF-UCL
Protein processingManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of BMP signaling pathwayManual Assertion Based On ExperimentTAS:BHF-UCL
Regulation of lipoprotein lipase activityTAS:Reactome
Secretion by cellManual Assertion Based On ExperimentIDA:BHF-UCL
Zygotic determination of anterior/posterior axis, embryoIEA:Ensembl
Cellular Location
Isoform PACE4A-I
Secreted
Isoform PACE4A-II
Secreted
Isoform PACE4C
Endoplasmic reticulum
Not secreted, remains probably in zymogen form in endoplasmic reticulum.
Isoform PACE4CS
Endoplasmic reticulum
Not secreted, remains probably in zymogen form in endoplasmic reticulum.
Isoform PACE4E-I
Endomembrane system ; Peripheral membrane protein
Retained intracellularly probably through a hydrophobic cluster in their C-terminus.
Isoform PACE4E-II
Endomembrane system ; Peripheral membrane protein
Retained intracellularly probably through a hydrophobic cluster in their C-terminus.
Isoform PACE4B
Secreted
More Infomation

Xu, M., Li, J., Xia, L., Du, Y., Wu, B., Shi, X., ... & Dong, Z. (2024). PCSK6 exacerbates Alzheimer's disease pathogenesis by promoting MT5-MMP maturation. Experimental Neurology, 374, 114688.

Oldham, J. M., Allen, R. J., Lorenzo-Salazar, J. M., Molyneaux, P. L., Ma, S. F., Joseph, C., ... & Noth, I. (2023). PCSK6 and survival in idiopathic pulmonary fibrosis. American Journal of Respiratory and Critical Care Medicine, 207(11), 1515-1524.

Li, C., Guo, Z., Liu, F., An, P., Wang, M., Yang, D., & Tang, Q. (2023). PCSK6 attenuates cardiac dysfunction in doxorubicin-induced cardiotoxicity by regulating autophagy. Free Radical Biology and Medicine, 203, 114-128.

Sethi, S., Moura, M. C., Madden, B., Debiec, H., Nasr, S. H., Larsen, C. P., ... & Caza, T. N. (2023). Proprotein convertase subtilisin/kexin type 6 (PCSK6) is a likely antigenic target in membranous nephropathy and nonsteroidal anti-inflammatory drug use. Kidney international, 104(2), 343-352.

Wu, X., Luo, Y., Wang, S., Li, Y., Bao, M., Shang, Y., ... & Liu, W. (2022). AKAP12 ameliorates liver injury via targeting PI3K/AKT/PCSK6 pathway. Redox Biology, 53, 102328.

Zhao, X., Zhang, X., Wu, Z., Mei, J., Li, L., & Wang, Y. (2021). Up-regulation of microRNA-135 or silencing of PCSK6 attenuates inflammatory response in preeclampsia by restricting NLRP3 inflammasome. Molecular Medicine, 27, 1-12.

Testa, G., Staurenghi, E., Giannelli, S., Sottero, B., Gargiulo, S., Poli, G., ... & Leonarduzzi, G. (2021). Up-regulation of PCSK6 by lipid oxidation products: A possible role in atherosclerosis. Biochimie, 181, 191-203.

Rykaczewska, U., Suur, B. E., Röhl, S., Razuvaev, A., Lengquist, M., Sabater-Lleal, M., ... & Matic, L. (2020). PCSK6 is a key protease in the control of smooth muscle cell function in vascular remodeling. Circulation research, 126(5), 571-585.

Kuhn, T. C., Knobel, J., Burkert-Rettenmaier, S., Li, X., Meyer, I. S., Jungmann, A., ... & Leuschner, F. (2020). Secretome analysis of cardiomyocytes identifies PCSK6 (proprotein convertase subtilisin/kexin type 6) as a novel player in cardiac remodeling after myocardial infarction. Circulation, 141(20), 1628-1644.

Yang, S. F., Chou, R. H., Lin, S. J., Li, S. Y., & Huang, P. H. (2019). Serum PCSK6 and corin levels are not associated with cardiovascular outcomes in patients undergoing coronary angiography. PLoS One, 14(12), e0226129.

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For research use only. Not intended for any clinical use.

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