PCSK6

The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can cleave precursor protein at their paired basic amino acid processing sites. Some of its substrates are - transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. This gene is thought to play a role in tumor progression. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]

Full Name

proprotein convertase subtilisin/kexin type 6

Function

Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues.

Biological Process

Determination of left/right symmetryIEA:Ensembl
Glycoprotein metabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Nerve growth factor productionManual Assertion Based On ExperimentIDA:BHF-UCL
Peptide hormone processingManual Assertion Based On ExperimentIDA:BHF-UCL
Protein processingManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of BMP signaling pathwayManual Assertion Based On ExperimentTAS:BHF-UCL
Regulation of lipoprotein lipase activityTAS:Reactome
Secretion by cellManual Assertion Based On ExperimentIDA:BHF-UCL
Zygotic determination of anterior/posterior axis, embryoIEA:Ensembl

Cellular Location

Isoform PACE4A-I
Secreted
Isoform PACE4A-II
Secreted
Isoform PACE4C
Endoplasmic reticulum
Not secreted, remains probably in zymogen form in endoplasmic reticulum.
Isoform PACE4CS
Endoplasmic reticulum
Not secreted, remains probably in zymogen form in endoplasmic reticulum.
Isoform PACE4E-I
Endomembrane system ; Peripheral membrane protein
Retained intracellularly probably through a hydrophobic cluster in their C-terminus.
Isoform PACE4E-II
Endomembrane system ; Peripheral membrane protein
Retained intracellularly probably through a hydrophobic cluster in their C-terminus.
Isoform PACE4B
Secreted