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Rabbit Anti-PDP1 Recombinant Antibody (CBYC-P277) (CBMAB-P1345-YC)

Provided herein is a Rabbit monoclonal antibody against Human Pyruvate Dehyrogenase Phosphatase Catalytic Subunit 1. The antibody can be used for immunoassay techniques, such as WB, IP.
See all PDP1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey
Clone
CBYC-P277
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Specificity
Human, Mouse, Rat, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Pyruvate Dehyrogenase Phosphatase Catalytic Subunit 1
Introduction
Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported; one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
Entrez Gene ID
Human54704
Mouse381511
Rat54705
Monkey699172
UniProt ID
HumanQ9P0J1
MouseQ3UV70
RatO88483
MonkeyF6RX47
Alternative Names
Pyruvate Dehyrogenase Phosphatase Catalytic Subunit 1; Protein Phosphatase 2C, Magnesium-Dependent, Catalytic Subunit; Pyruvate Dehydrogenase Phosphatase Catalytic Subunit 1; Protein Phosphatase, Mg2+/Mn2+ Dependent 2A; EC 3.1.3.43; PDPC 1; PDP 1; PPM2C; PDP;
Function
Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex.
Biological Process
Peptidyl-threonine dephosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of pyruvate dehydrogenase activityManual Assertion Based On ExperimentIBA:GO_Central
Protein dephosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Mitochondrion matrix
Involvement in disease
Pyruvate dehydrogenase phosphatase deficiency (PDP deficiency):
Results in lactic acidosis leading to neurological dysfunction.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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