WB 1:500-1:2000; IP 1:20-1:50
A phospho specific peptide corresponding to residues surrounding Y223 of human BTK
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms.
BTK; AGMX1; AT; ATK; BPK; IMD1; PSCTK1; XLA; Bruton tyrosine kinase