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Recombinant Rabbit Anti-Phospho-EIF2AK2-T446 Antibody (CBAb260) (CBMAB-Ab260-LY)

The product is antibody recognizes Phospho-EIF2AK2-T446. The antibody immunoassay techniques such as: WB 1:500-1:2000; IHC 1:50-1:200; IF 1:50-1:200; IP 1:20-1:50.
See all Phospho-EIF2AK2-T446 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBAb260
Antibody Isotype
IgG
Application
WB 1:500-1:2000; IHC 1:50-1:200; IF 1:50-1:200; IP 1:20-1:50

Basic Information

Immunogen
A phospho specific peptide corresponding to residues surrounding T446 of human EIF2AK2
Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Introduction
The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene.
Entrez Gene ID
5610
UniProt ID
P19525
Alternative Names
EIF2AK2; EIF2AK1; PKR; PPP1R83; PRKR; eukaryotic translation initiation factor 2 alpha kinase 2
Function
5610
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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