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Mouse Anti-PLA2R1 Recombinant Antibody (CBYC-P417) (CBMAB-P2004-YC)

Provided herein is a Mouse monoclonal antibody against Human Phospholipase A2 receptor 1. The antibody can be used for immunoassay techniques, such as WB, FC, ELISA, IHC.
See all PLA2R1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYC-P417
Antibody Isotype
IgG2b
Application
WB, FC, ELISA, IHC

Basic Information

Immunogen
Human PLA2R extracellular sequence N-C3 (containing domains N-terminal Cysteine rich-FibII-CTLD1-CTLD2-CTLD3)
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
0.02% sodium azide
Concentration
1 mg/mL
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Phospholipase A2 receptor 1
Introduction
PLA2R1 represents a phospholipase A2 receptor. The encoded protein likely exists as both a transmembrane form and a soluble form. The transmembrane receptor may play a role in clearance of phospholipase A2, thereby inhibiting its action. Polymorphisms at this locus have been associated with susceptibility to idiopathic membranous nephropathy.
Entrez Gene ID
22925
UniProt ID
Q13018
Alternative Names
CLEC13C; PLA2-R; PLA2G1R; PLA2IR; PLA2R
Function
Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phospholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in pro-inflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B (PubMed:15611272, PubMed:7721806).
In podocytes, binding of sPLA2-IB/PLA2G1B can regulate podocyte survival and glomerular homeostasis (PubMed:25335547).
Biological Process
Negative regulation of arachidonic acid secretionISS:UniProtKB
Negative regulation of phospholipase A2 activityISS:UniProtKB
Oxidative stress-induced premature senescenceManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of arachidonic acid secretionISS:UniProtKB
Positive regulation of cytokine productionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of DNA damage response, signal transduction by p53 class mediatorManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of podocyte apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Reactive oxygen species metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Receptor-mediated endocytosisIDA:UniProtKB
Replicative senescenceManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cell membrane
Soluble secretory phospholipase A2 receptor
Secreted
Isoform 2
Secreted
Topology
Extracellular: 21-1397
Helical: 1398-1418
Cytoplasmic: 1419-1463
PTM
The secretory phospholipase A2 receptor form may be produced by the action of metalloproteinases. It contains all extracellular domains and only lacks transmembrane and cytosolic regions. It is however unclear whether this form is produced by proteolytic cleavage as suggested by some experiments, or by alternative splicing, as in the case of isoform 2 that shares all characteristics of secretory phospholipase A2 receptor form (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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