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Mouse Anti-PLPP1 Recombinant Antibody (1H4) (CBMAB-P2172-YC)

Provided herein is a Mouse monoclonal antibody against Human Phospholipid Phosphatase 1. The antibody can be used for immunoassay techniques, such as WB, IHC-P.
See all PLPP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1H4
Antibody Isotype
IgG1
Application
WB, IHC-P

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Phospholipid Phosphatase 1
Introduction
PLPP1 (Phospholipid Phosphatase 1) is a protein coding gene. Among its related pathways are Immune response Fc epsilon RI pathway and Glycerolipid metabolism. An important paralog of the gene is PLPP2.
Entrez Gene ID
8611
UniProt ID
O14494
Alternative Names
Hic53; Hpic53; LPP-1; LPP1; PAP-2a; PAP2-alpha; PAP2a; mPAP
Function
Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P (PubMed:9305923, PubMed:9705349, PubMed:9607309, PubMed:10962286, PubMed:17379599).
Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound (PubMed:9607309).
Through its extracellular phosphatase activity allows both the hydrolysis and the cellular uptake of these bioactive lipid mediators from the milieu, regulating signal transduction in different cellular processes (PubMed:10962286, PubMed:12909631, PubMed:15461590, PubMed:17379599).
It is for instance essential for the extracellular hydrolysis of S1P and subsequent conversion into intracellular S1P (PubMed:17379599).
Involved in the regulation of inflammation, platelets activation, cell proliferation and migration among other processes (PubMed:12909631, PubMed:15461590).
May also have an intracellular activity to regulate phospholipid-mediated signaling pathways (By similarity).
Biological Process
Androgen receptor signaling pathway1 PublicationNAS:UniProtKB
Ceramide metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Intracellular steroid hormone receptor signaling pathwayManual Assertion Based On ExperimentTAS:UniProtKB
Negative regulation of cell population proliferation1 PublicationNAS:UniProtKB
Phospholipid dephosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Phospholipid metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Protein kinase C-activating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:UniProtKB
Regulation of lipid metabolic process1 PublicationNAS:UniProtKB
Signal transductionManual Assertion Based On ExperimentIMP:UniProtKB
Sphingolipid biosynthetic processTAS:Reactome
Sphingosine metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cell membrane
Apical cell membrane
Membrane raft
Membrane, caveola
Topology
Cytoplasmic: 1-6
Helical: 7-27
Extracellular: 28-53
Helical: 54-74
Cytoplasmic: 75-94
Helical: 95-115
Extracellular: 116-164
Helical: 165-185
Cytoplasmic: 186-199
Helical: 200-220
Extracellular: 221-229
Helical: 230-250
Cytoplasmic: 251-284
PTM
N-glycosylated (PubMed:9305923, PubMed:10962286).
N-linked sugars are of the complex type. N-glycosylation is not required for the phosphatase activity (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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