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Mouse Anti-PNP Recombinant Antibody (6E5) (CBMAB-N4098-WJ)

This product is a Mouse antibody that recognizes PNP. The antibody 6E5 can be used for immunoassay techniques such as: ELISA, WB.
See all PNP antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
6E5
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Purine Nucleoside Phosphorylase
Introduction
PNP is a gene encodes an enzyme which reversibly catalyzes the phosphorolysis of purine nucleosides. The enzyme is trimeric, containing three identical subunits. Mutations which result in nucleoside phosphorylase deficiency result in defective T-cell (cell-mediated) immunity but can also affect B-cell immunity and antibody responses. Neurologic disorders may also be apparent in patients with immune defects. A known polymorphism at aa position 51 that does not affect enzyme activity has been described. A pseudogene has been identified on chromosome 2.
Entrez Gene ID
4860
UniProt ID
P00491
Alternative Names
NP, PRO1837, PUNP
Function
Catalyzes the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (PubMed:9305964, PubMed:23438750).
Preferentially acts on 6-oxopurine nucleosides including inosine and guanosine (PubMed:9305964).
Biological Process
Allantoin metabolic processManual Assertion Based On ExperimentIDA:MGI
dAMP catabolic processManual Assertion Based On ExperimentIDA:MGI
Deoxyadenosine catabolic processManual Assertion Based On ExperimentIDA:MGI
Deoxyinosine catabolic processManual Assertion Based On ExperimentIDA:MGI
Immune responseManual Assertion Based On ExperimentIMP:UniProtKB
IMP catabolic processManual Assertion Based On ExperimentIDA:MGI
Inosine catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Nicotinamide riboside catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Nucleobase-containing compound metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Nucleotide biosynthetic processManual Assertion Based On ExperimentIGI:UniProtKB
Positive regulation of alpha-beta T cell differentiationManual Assertion Based On ExperimentIDA:MGI
Positive regulation of interleukin-2 productionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of T cell proliferationManual Assertion Based On ExperimentIDA:MGI
Purine ribonucleoside salvageIEA:UniProtKB-KW
Purine-containing compound salvageManual Assertion Based On ExperimentIDA:UniProtKB
Response to xenobiotic stimulusManual Assertion Based On ExperimentIMP:UniProtKB
Urate biosynthetic processManual Assertion Based On ExperimentIDA:MGI
Cellular Location
Cytoplasm
Involvement in disease
Purine nucleoside phosphorylase deficiency (PNPD):
A disorder that interrupts both the catabolism of inosine into hypoxanthine and guanosine into guanine, and leads to the accumulation of guanosine, inosine, and their deoxified by-products. The main clinical presentation is recurrent infections due to severe T-cell immunodeficiency. Some patients also have neurologic impairment.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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