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Mouse Anti-POMK Recombinant Antibody (CBXS-4373) (CBMAB-S1616-CQ)

This product is a mouse antibody that recognizes POMK. The antibody CBXS-4373 can be used for immunoassay techniques such as: WB, IHC.
See all POMK antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4373
Antibody Isotype
IgG1
Application
WB, IHC

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 141-350 of human SGK196 (NP_115613) produced in E.coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
protein-O-mannose kinase
Entrez Gene ID
84197
UniProt ID
Q9H5K3
Alternative Names
MDDGA12; MDDGC12; SGK196
Function
Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif.
Biological Process
Brain developmentManual Assertion Based On ExperimentTAS:UniProtKB
Carbohydrate phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Learning or memoryIEA:Ensembl
Neuromuscular processIEA:Ensembl
Protein O-linked glycosylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein phosphorylationIEA:InterPro
Sensory perception of painIEA:Ensembl
Cellular Location
Endoplasmic reticulum membrane
Involvement in disease
Muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A12 (MDDGA12):
An autosomal recessive disorder characterized by congenital muscular dystrophy associated with cobblestone lissencephaly and other brain anomalies, eye malformations, profound intellectual disability, and death usually in the first years of life. Included diseases are the more severe Walker-Warburg syndrome and the slightly less severe muscle-eye-brain disease.
Muscular dystrophy-dystroglycanopathy limb-girdle C12 (MDDGC12):
An autosomal recessive limb-girdle congenital muscular dystrophy, characterized by muscle weakness and delayed motor development in association with cognitive impairment.
Topology
Cytoplasmic: 1-20
Helical: 21-43
Lumenal: 44-350
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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