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Rabbit Anti-POMT1 Recombinant Antibody (EPR11680) (CBMAB-1676-CN)

This product is a rabbit antibody that recognizes POMT1 of human. The antibody EPR11680 can be used for immunoassay techniques such as: IP, WB.
See all POMT1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
EPR11680
Antibody Isotype
IgG
Application
IP, WB

Basic Information

Immunogen
Synthetic peptide within Human POMT1 aa. 300-400 (Cysteine residue).
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
49% PBS, 50% Glycerol, 0.05% BSA, pH 7.2
Preservative
0.01% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Protein O-Mannosyltransferase 1
Introduction
The protein encoded by this gene is an O-mannosyltransferase that requires interaction with the product of the POMT2 gene for enzymatic function. The encoded protein is found in the membrane of the endoplasmic reticulum. Defects in this gene are a cause of Walker-Warburg syndrome (WWS) and limb-girdle muscular dystrophy type 2K (LGMD2K). Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient.
Entrez Gene ID
10585
UniProt ID
Q9Y6A1
Alternative Names
RT; LGMD2K; MDDGA1; MDDGB1; MDDGC1
Function
Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient (PubMed:12369018, PubMed:14699049, PubMed:28512129).
Essentially dedicated to O-mannosylation of alpha-DAG1 and few other proteins but not of cadherins and protocaherins (PubMed:28512129).
Biological Process
Extracellular matrix organizationIEA:Ensembl
Positive regulation of protein O-linked glycosylationIEA:Ensembl
Protein O-linked glycosylationManual Assertion Based On ExperimentTAS:ProtInc
Protein O-linked mannosylationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Endoplasmic reticulum membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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