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Rabbit Anti-POU2AF1 Recombinant Antibody (RM378) (CBMAB-BR394LY)

The product is antibody recognizes POU2AF1. The antibody RM378 immunoassay techniques such as: IHC, WB.
See all POU2AF1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
RM378
Antibody Isotype
IgG
Application
IHC: 1:300-1:500 dilution, WB: 0.1-0.5 μg/ml

Basic Information

Immunogen
A peptide corresponding to the C-terminus of human BOB-1/OBF-1
Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol, 1% BSA
Preservative
0.09% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
POU class 2 homeobox associating factor 1
Entrez Gene ID
5450
UniProt ID
Q16633
Alternative Names
POU domain class 2-associating factor 1;B-cell-specific coactivator OBF-1;BOB-1;OCA-B;OCT-binding factor 1;POU2AF1;OBF1;
Function
Transcriptional coactivator that specifically associates with either POU2F1/OCT1 or POU2F2/OCT2 (PubMed:7859290).
It boosts the POU2F1/OCT1 mediated promoter activity and to a lesser extent, that of POU2F2/OCT2 (PubMed:7779176).
It has no intrinsic DNA-binding activity. It recognizes the POU domains of POU2F1/OCT1 and POU2F2/OCT2 (PubMed:7779176).
It is essential for the response of B-cells to antigens and required for the formation of germinal centers (PubMed:7623806, PubMed:7859290).
Regulates IL6 expression in B cells as POU2F2/OCT2 coactivator (By similarity).
Biological Process
Cellular response to virusISS:UniProtKB
Germinal center B cell differentiationISS:UniProtKB
Humoral immune responseManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of interleukin-6 productionISS:UniProtKB
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIGI:CAFA
Cellular Location
Nucleus
Involvement in disease
A chromosomal aberration involving POU2AF1/OBF1 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with BCL6.
PTM
Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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