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Mouse Anti-PPIL1 Recombinant Antibody (2D1) (CBMAB-P2536-YC)

Provided herein is a Mouse monoclonal antibody against Human Peptidylprolyl Isomerase Like 1. The antibody can be used for immunoassay techniques, such as WB, IHC.
See all PPIL1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2D1
Antibody Isotype
IgG1
Application
WB, IHC

Basic Information

Immunogen
Full length human recombinant protein of human PPIL1 (NP_057143) produced in E. coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
peptidylprolyl isomerase (cyclophilin)-like 1
Introduction
PPIL1 is a member of the cyclophilin family of peptidylprolyl isomerases (PPIases). The cyclophilins are a highly conserved, ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. Based on similarity to other PPIases, this protein could accelerate the folding of proteins and might catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Entrez Gene ID
51645
UniProt ID
Q9Y3C6
Alternative Names
CGI-124; CYPL1; PPIase; hCyPX
Function
Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28076346, PubMed:33220177).
PPIases accelerate the folding of proteins. Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (PubMed:16595688).
Catalyzes prolyl peptide bond isomerization in CDC40/PRP17 (PubMed:33220177).
Plays an important role in embryonic brain development; this function is independent of its isomerase activity (PubMed:33220177).
Biological Process
Embryonic brain developmentManual Assertion Based On ExperimentIMP:UniProtKB
mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Protein foldingIEA:InterPro
Protein peptidyl-prolyl isomerizationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Nucleus
Involvement in disease
Pontocerebellar hypoplasia 14 (PCH14):
A form of pontocerebellar hypoplasia, a disorder characterized by structural defects of the pons and cerebellum, evident upon brain imaging. PCH14 is a severe autosomal recessive form characterized by progressive microcephaly, and poor or absent psychomotor development with severely impaired intellectual development apparent from birth. Other features may include hypotonia, spastic quadriplegia, and early-onset seizures. Early death may occur in some patients.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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