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Mouse Anti-PPP5C Recombinant Antibody (CB66A) (CBMAB-CA066LY)

The product is antibody recognizes PPP5C. The antibody CB66A immunoassay techniques such as: ELISA, WB.
See all PPP5C antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CB66A
Antibody Isotype
IgG2a
Application
ELISA, WB

Basic Information

Immunogen
Purified recombinant Human PPP5C protein fragments expressed in E.coli.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
PPP5C
Entrez Gene ID
Human5536
Mouse19060
Rat65179
UniProt ID
HumanP53041
MouseQ60676
RatP53042
Function
Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT (PubMed:14734805, PubMed:14764652, PubMed:14871926, PubMed:15383005, PubMed:15546861, PubMed:16260606, PubMed:16790549, PubMed:16892053, PubMed:19176521, PubMed:19948726, PubMed:21144835, PubMed:22399290, PubMed:22781750, PubMed:23102700, PubMed:9000529, PubMed:30699359).
Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses (PubMed:14734805, PubMed:14764652, PubMed:14871926, PubMed:15383005, PubMed:15546861, PubMed:16260606, PubMed:16790549, PubMed:16892053, PubMed:19176521, PubMed:19948726, PubMed:21144835, PubMed:22399290, PubMed:22781750, PubMed:23102700, PubMed:9000529, PubMed:30699359).
Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1 (PubMed:14871926, PubMed:16260606, PubMed:21144835).
Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress (PubMed:23102700).
Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function (By similarity).
Also dephosphorylates and inhibits the anti-adipogenic effect of NR3C1 (By similarity).
Regulates the circadian rhythms, through the dephosphorylation and activation of CSNK1E (PubMed:16790549).
May modulate TGF-beta signaling pathway by the regulation of SMAD3 phosphorylation and protein expression levels (PubMed:22781750).
Dephosphorylates and may play a role in the regulation of TAU/MAPT (PubMed:15546861).
Through their dephosphorylation, may play a role in the regulation of ions channels such as KCNH2 (By similarity).
Dephosphorylate FNIP1, disrupting interaction with HSP90AA1/Hsp90 (PubMed:30699359).
Biological Process
Double-strand break repairTAS:Reactome
MAPK cascadeTAS:Reactome
Mitotic cell cycleManual Assertion Based On ExperimentTAS:ProtInc
Peptidyl-serine dephosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Peptidyl-threonine dephosphorylationManual Assertion Based On ExperimentTAS:ARUK-UCL
Positive regulation of I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentHMP:UniProtKB
Protein dephosphorylationManual Assertion Based On ExperimentTAS:ProtInc
Response to arachidonic acidBy SimilarityISS:ARUK-UCL
Response to lead ionISS:ARUK-UCL
Response to morphineIEA:Ensembl
Transcription, DNA-templatedManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Nucleus
Cytoplasm
Cell membrane
Predominantly nuclear (PubMed:15383005).
But also present in the cytoplasm (PubMed:15383005).
Translocates from the cytoplasm to the plasma membrane in a RAC1-dependent manner (PubMed:19948726).
PTM
Activated by at least two different proteolytic cleavages producing a 56 kDa and a 50 kDa form.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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