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Mouse Anti-PTPRN2 Recombinant Antibody (7F8) (CBMAB-P3484-YC)

Provided herein is a Mouse monoclonal antibody against Human Protein tyrosine phosphatase, receptor type N2. The antibody can be used for immunoassay techniques, such as ELISA, RNAi, WB.
See all PTPRN2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
7F8
Antibody Isotype
IgG1, κ
Application
ELISA, RNAi, WB

Basic Information

Immunogen
PTPRN2 (NP_002838, 108-212 aa) partial recombinant protein with GST tag. Immunogen sequence: ELADLPKTYL RRPEASSPAR PSKHSVGSER RYSREGGAAL ANALRRHLPF LEALSQAPAS DVLARTHTAQ DRPPAEGDDR FSESILTYVA HTSALTYPPG PRTQL
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 108-212

Target

Full Name
protein tyrosine phosphatase, receptor type, N polypeptide 2
Introduction
PTPRN2 is a protein with sequence similarity to receptor-like protein tyrosine phosphatases. However, tyrosine phosphatase activity has not been experimentally validated for this protein. Studies of the rat ortholog suggest that the encoded protein may instead function as a phosphatidylinositol phosphatase with the ability to dephosphorylate phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-diphosphate, and this function may be involved in the regulation of insulin secretion.
Entrez Gene ID
5799
UniProt ID
Q92932
Alternative Names
IA-2beta; R-PTP-N2; IAR; ICAAR; PTPRP
Function
Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli. Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (By similarity).
Required to maintain normal levels of renin expression and renin release (By similarity).
May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (By similarity).
Has phosphatidylinositol phosphatase activity; the PIPase activity is involved in its ability to regulate insulin secretion. Can dephosphorylate phosphatidylinositol 4,5-biphosphate (PI(4,5)P2), phosphatidylinositol 5-phosphate and phosphatidylinositol 3-phosphate (By similarity).
Regulates PI(4,5)P2 level in the plasma membrane and localization of cofilin at the plasma membrane and thus is indirectly involved in regulation of actin dynamics related to cell migration and metastasis; upon hydrolyzation of PI(4,5)P2 cofilin is released from the plasma membrane and acts in the cytoplasm in severing F-actin filaments (PubMed:26620550).
Biological Process
Insulin secretion involved in cellular response to glucose stimulusISS:UniProtKB
Lipid metabolic processIEA:UniProtKB-KW
Neurotransmitter secretionISS:UniProtKB
Protein dephosphorylationManual Assertion Based On ExperimentTAS:ProtInc
Regulation of secretionManual Assertion Based On ExperimentIBA:GO_Central
Involvement in disease
Autoantigen in insulin-dependent diabetes mellitus (IDDM).
Topology
Extracellular: 22-615
Helical: 616-636
Cytoplasmic: 637-1015
PTM
Subject to proteolytic cleavage at multiple sites.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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