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Mouse Anti-PTPRT Recombinant Antibody (10g82) (CBMAB-P3491-YC)

Provided herein is a Mouse monoclonal antibody against Human Protein tyrosine phosphatase, receptor type T. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all PTPRT antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
10g82
Antibody Isotype
IgG1
Application
ELISA, WB

Basic Information

Immunogen
Recombinant protein encoding aa1-321 of human PTP1B
Specificity
Human, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
0.09% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Protein tyrosine phosphatase, receptor type T
Introduction
PTPRT is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. The protein domain structure and the expression pattern of the mouse counterpart of this PTP suggest its roles in both signal transduction and cellular adhesion in the central nervous system.
Entrez Gene ID
Human11122
Mouse19281
UniProt ID
HumanO14522
MouseQ99M80
Alternative Names
RPTPrho
Function
May be involved in both signal transduction and cellular adhesion in the CNS.
Biological Process
Cell adhesion1 PublicationNAS:UniProtKB
Cellular response to interleukin-6Manual Assertion Based On ExperimentIDA:ARUK-UCL
Homophilic cell adhesion via plasma membrane adhesion moleculesManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of cell migrationManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of receptor signaling pathway via STATManual Assertion Based On ExperimentIDA:ARUK-UCL
Peptidyl-tyrosine dephosphorylationManual Assertion Based On ExperimentIDA:ARUK-UCL
Peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activityManual Assertion Based On ExperimentIDA:ARUK-UCL
Protein dephosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Signal transduction1 PublicationNAS:UniProtKB
Transmembrane receptor protein tyrosine kinase signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Membrane
Topology
Extracellular: 26-747
Helical: 748-768
Cytoplasmic: 769-1441
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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