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Mouse Anti-RAB11A Recombinant Antibody (1565CT164.36.80) (CBMAB-R0678-CN)

This product is a Mouse antibody that recognizes RAB11A. The antibody 1565CT164.36.80 can be used for immunoassay techniques such as: WB, IHC-P.
See all RAB11A antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
1565CT164.36.80
Antibody Isotype
IgG1, κ
Application
WB, IHC-P

Basic Information

Immunogen
A purified recombinant protein of human RAB11A
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
RAB11A, member RAS oncogene family
Introduction
The protein encoded by this gene belongs to the Rab family of the small GTPase superfamily. It is associated with both constitutive and regulated secretory pathways, and may be involved in protein transport. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
Entrez Gene ID
Human8766
Mouse53869
Rat81830
UniProt ID
HumanP62491
MouseP62492
RatP62494
Alternative Names
RAB11A, Member RAS Oncogene Family; Rab-11; YL8; RAB 11A, Member Oncogene Family; Ras-Related Protein Rab-11A; RAB11;
Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11A regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes. May also play a role in melanosome transport and release from melanocytes.
Biological Process
Biological Process amyloid-beta clearance by transcytosisManual Assertion Based On ExperimentIGI:ARUK-UCL
Biological Process astral microtubule organizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process establishment of protein localization to membraneManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process establishment of protein localization to organelleManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process establishment of vesicle localizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process exocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process exosomal secretionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process melanosome transportISS:UniProtKB
Biological Process mitotic metaphase plate congressionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process mitotic spindle assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process multivesicular body assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process neuron projection developmentManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process neurotransmitter receptor transport, endosome to postsynaptic membraneManual Assertion Based On ExperimentIBA:GO_Central
Biological Process plasma membrane to endosome transport1 PublicationNAS:UniProtKB
Biological Process positive regulation of epithelial cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of G2/M transition of mitotic cell cycleManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein localization to cell surfaceIEA:Ensembl
Biological Process protein localization to plasma membraneManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of cytokinesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of multivesicular body sizeManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of vesicle-mediated transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process vesicle-mediated transportManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cell membrane
Recycling endosome membrane
Cleavage furrow
Cytoplasmic vesicle, phagosome
Cytoplasmic vesicle membrane
Translocates with RAB11FIP2 from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane (PubMed:11994279).
Localizes to the cleavage furrow (PubMed:15601896).
Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB8A in apical membrane initiation sites (AMIS) during the generation of apical surface and lumenogenesis (PubMed:20890297).
Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211).
PTM
(Microbial infection) Glycosylated on arginine residues by S.typhimurium protein Ssek3.
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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