RAB11A

The protein encoded by this gene belongs to the Rab family of the small GTPase superfamily. It is associated with both constitutive and regulated secretory pathways, and may be involved in protein transport. Two transcript variants encoding different isoforms have been found for this gene.

RAB11A, member RAS oncogene family

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11A regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes. May also play a role in melanosome transport and release from melanocytes.

Biological Process amyloid-beta clearance by transcytosisManual Assertion Based On ExperimentIGI:ARUK-UCL
Biological Process astral microtubule organizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process establishment of protein localization to membraneManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process establishment of protein localization to organelleManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process establishment of vesicle localizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process exocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process exosomal secretionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process melanosome transportISS:UniProtKB
Biological Process mitotic metaphase plate congressionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process mitotic spindle assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process multivesicular body assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process neuron projection developmentManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process neurotransmitter receptor transport, endosome to postsynaptic membraneManual Assertion Based On ExperimentIBA:GO_Central
Biological Process plasma membrane to endosome transport1 PublicationNAS:UniProtKB
Biological Process positive regulation of epithelial cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of G2/M transition of mitotic cell cycleManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein localization to cell surfaceIEA:Ensembl
Biological Process protein localization to plasma membraneManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of cytokinesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of multivesicular body sizeManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of vesicle-mediated transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process vesicle-mediated transportManual Assertion Based On ExperimentIDA:UniProtKB

Cell membrane
Recycling endosome membrane
Cleavage furrow
Cytoplasmic vesicle, phagosome
Cytoplasmic vesicle membrane
Translocates with RAB11FIP2 from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane (PubMed:11994279).
Localizes to the cleavage furrow (PubMed:15601896).
Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB8A in apical membrane initiation sites (AMIS) during the generation of apical surface and lumenogenesis (PubMed:20890297).
Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211).

(Microbial infection) Glycosylated on arginine residues by S.typhimurium protein Ssek3.