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Rabbit Anti-RDH5 Recombinant Antibody (EPR15191) (CBMAB-1758-CN)

This product is a rabbit antibody that recognizes RDH5 of human. The antibody EPR15191 can be used for immunoassay techniques such as: IF, IP, WB.
See all RDH5 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EPR15191
Antibody Isotype
IgG
Application
IF, IP, WB

Basic Information

Immunogen
Synthetic peptide within Human RDH5 aa. 50-150.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
59% PBS, 40% Glycerol, 0.05% BSA
Preservative
0.01% Sodium azide
Concentration
0.154 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Retinol Dehydrogenase 5
Introduction
This gene encodes an enzyme belonging to the short-chain dehydrogenases/reductases (SDR) family. This retinol dehydrogenase functions to catalyze the final step in the biosynthesis of 11-cis retinaldehyde, which is the universal chromophore of visual pigments. It also able to oxidize 9-cis-retinol and 13-cis-retinol, but not all-trans-retinol. Active in the presence of NAD as cofactor but not in the presence of NADP.
Entrez Gene ID
Human5959
Mouse19682
Rat366791
UniProt ID
HumanQ92781
MouseO55240
RatA0A0G2K1R4
Alternative Names
RDH1; 9cRDH; SDR9C5; HSD17B9
Function
Catalyzes the oxidation of cis-isomers of retinol, including 11-cis-, 9-cis-, and 13-cis-retinol in an NAD-dependent manner (PubMed:11675386, PubMed:10588954, PubMed:9931293, PubMed:9115228).
Has no activity towards all-trans retinal (By similarity).
Plays a significant role in 11-cis retinol oxidation in the retinal pigment epithelium cells (RPE). Also recognizes steroids (androsterone, androstanediol) as its substrates (PubMed:9931293, PubMed:29541409).
Biological Process
Biological Process response to stimulusIEA:UniProtKB-KW
Biological Process retinoid metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process retinol metabolic processIEA:UniProtKB-UniPathway
Biological Process steroid metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process visual perceptionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Endoplasmic reticulum membrane
Involvement in disease
Fundus albipunctatus (FALBI):
A form of fleck retina disease characterized by discrete uniform white dots over the entire fundus with greatest density in the mid-periphery and no macular involvement. Night blindness occurs. Inheritance can be autosomal dominant or autosomal recessive.
Topology
Helical: 1-21
Lumenal: 22-288
Helical: 289-309
Cytoplasmic: 310-318
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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