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Mouse Anti-Rotavirus VP6 Recombinant Antibody (Rota-VP6) (CBMAB-V208-1700-CQ)

This product is a mouse antibody that recognizes Rotavirus VP6. The antibody Rota-VP6 can be used for immunoassay techniques such as: ELISA, WB, IF, IHC, IP.
See all Rotavirus VP6 antibodies

Summary

Host Animal
Mouse
Specificity
Rotavirus
Clone
Rota-VP6
Antibody Isotype
IgG2b
Application
ELISA, WB, IF, IHC, IP

Basic Information

Immunogen
UZ-purified Rotavirus WA (Type G1)
Specificity
Rotavirus
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Rotavirus VP6
Introduction
The inner capsid protein, VP6, is a trimer representing 51% of the virion mass. According to the antigenic variation of VP6, RVs are classified into seven groups (A to G). Depending on the presence or absence of two different epitopes in the VP6 protein, group A RV strains are further divided into subgroups (Sb) I, II, I+II, and no I no II. Despite the different subgroups mentioned, VP6 is a strongly conserved protein among all group A RVs (>90% amino acid homology). It is highly immunogenic and constitutes the target antigen of most immunodiagnosis tests for group A RV detection
Alternative Names
Capsid protein VP6; capsid protein VP6; protein VP6; VP6
Function
Intermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices (PubMed:11285213).
This capsid constitutes the middle concentric layer of the viral mature particle (PubMed:11285213).
The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nascent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes (By similarity).
VP6 is required for the transcription activity of the DLP (PubMed:12097594).
Biological Process
Fusion of virus membrane with host plasma membrane
Cellular Location
Virion
Component of the intermediate capsid (PubMed:11285213).
Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging (Potential)
PTM
The N-terminus is blocked.
Sumoylated with SUMO1 and SUMO2. Sumoylation of viral proteins seems to have a positive role on viral replication.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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