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Rat Anti-RSPO2 Recombinant Antibody (879709) (CBMAB-R3746-CN)

This product is a Rat antibody that recognizes RSPO2. The antibody 879709 can be used for immunoassay techniques such as: Neut.
See all RSPO2 antibodies

Summary

Host Animal
Rat
Specificity
Human
Clone
879709
Antibody Isotype
IgG1
Application
Neut

Basic Information

Immunogen
Mouse myeloma cell line NS0-derived recombinant human R-Spondin 2, Met1-Gly205, Accession # Q6UXX9
Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
LYOPH
Buffer
PBS, Trehalose
Concentration
LYOPH

Target

Full Name
R-Spondin 2
Introduction
This gene encodes a member of the R-spondin family of proteins. These proteins are secreted ligands of leucine-rich repeat containing G protein-coupled receptors that enhance Wnt signaling through the inhibition of ubiquitin E3 ligases. A chromosomal translocation including this locus that results in the formation of a gene fusion has been identified in multiple human cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Entrez Gene ID
340419
UniProt ID
Q6UXX9
Alternative Names
R-Spondin 2; Roof Plate-Specific Spondin-2; R-Spondin 2 Homolog (Xenopus Laevis); R-Spondin 2 Homolog; R-Spondin-2; CRISTIN2; HRspo2;
Function
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway (PubMed:21909076, PubMed:21727895, PubMed:22615920).
During embryonic development, plays a crucial role in limb specification, amplifying the Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3, hence governing the number of limbs an embryo should form (PubMed:29769720).
Biological Process
Biological Process bone mineralizationIEA:Ensembl
Biological Process canonical Wnt signaling pathwayIEA:Ensembl
Biological Process dopaminergic neuron differentiationIEA:Ensembl
Biological Process embryonic forelimb morphogenesisIEA:Ensembl
Biological Process embryonic hindlimb morphogenesisIEA:Ensembl
Biological Process epithelial tube branching involved in lung morphogenesisIEA:Ensembl
Biological Process limb developmentManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process lung growthIEA:Ensembl
Biological Process negative regulation of odontogenesis of dentin-containing toothIEA:Ensembl
Biological Process osteoblast differentiationIEA:Ensembl
Biological Process positive regulation of canonical Wnt signaling pathwayIEA:Ensembl
Biological Process positive regulation of Wnt signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process trachea cartilage morphogenesisIEA:Ensembl
Cellular Location
Secreted
Involvement in disease
Tetraamelia syndrome 2 (TETAMS2):
A form of tetraamelia, a rare disease characterized by rudimentary appendages or complete absence of all four limbs, and other anomalies such as craniofacial, nervous system, pulmonary, skeletal and urogenital defects. TETAMS2 patients manifest limb deformities, bilateral agenesis of the lungs, abnormalities of the pulmonary vasculature, labioscrotal fold aplasia, and dysmorphic features including bilateral cleft lip/palate, ankyloglossia, mandibular hypoplasia, and microretrognathia. TETAMS2 transmission pattern is consistent with autosomal recessive inheritance.
Humerofemoral hypoplasia with radiotibial ray deficiency (HHRRD):
A severe disease characterized by reduction of all four limbs as well as hypoplasia of the upper limb girdle and pelvis. Rudimentary finger- or toe-like appendages may be present. HHRRD transmission pattern is consistent with autosomal recessive inheritance.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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