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Mouse Anti-RUNX1T1 Recombinant Antibody (1H1) (CBMAB-R3862-CN)

This product is a Mouse antibody that recognizes RUNX1T1. The antibody 1H1 can be used for immunoassay techniques such as: WB, FC, IF.
See all RUNX1T1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1H1
Antibody Isotype
IgG1
Application
WB, FC, IF

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
Introduction
This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
Entrez Gene ID
862
UniProt ID
Q06455
Alternative Names
RUNX1 Translocation Partner 1; Core-Binding Factor, Runt Domain, Alpha Subunit 2; Translocated To, 1; Cyclin D-Related; Runt Related Transcription Factor 1; Translocated To, 1 (Cyclin D Related); Zinc Finger MYND Domain-Containing Protein 2; Eight Twenty One Protein; CBFA2T1; AML1T1; ZMYND2; MTG8; CDR;
Function
Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199, PubMed:10688654).
Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453).
Can repress transactivation mediated by TCF12 (PubMed:16803958).
Acts as a negative regulator of adipogenesis (By similarity).
The AML1-MTG8/ETO fusion protein frequently found in leukemic cells is involved in leukemogenesis and contributes to hematopoietic stem/progenitor cell self-renewal (PubMed:23812588).
Biological Process
Biological Process negative regulation of DNA-templated transcriptionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of fat cell differentiationISS:UniProtKB
Cellular Location
Nucleus
Colocalizes with ATN1 in discrete nuclear dots.
Involvement in disease
A chromosomal aberration involving RUNX1T1 is a cause of acute myeloid leukemia (AML-M2). Translocation t(8;21)(q22;q22) with RUNX1/AML1.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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