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Mouse Anti-S. cerevisiae COX1 Recombinant Antibody (CBMW-H1377) (CBMAB-V208-1735-FY)

This product is mouse antibody that recognizes S. cerevisiae COX1. The antibody CBMW-H1377 can be used for immunoassay techniques such as: WB.
See all S. cerevisiae COX1 antibodies

Summary

Host Animal
Mouse
Specificity
S. cerevisiae
Clone
CBMW-H1377
Antibody Isotype
IgG2b
Application
WB

Basic Information

Specificity
S. cerevisiae
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Saccharomyces Cerevisiae Cytochrome C Oxidase Subunit 1
Introduction
Saccharomyces cerevisiae is a species of yeast. It has been instrumental to winemaking, baking, and brewing since ancient times.
UniProt ID
P00401
Alternative Names
MTCO1
Function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of COX2 and heme A of COX1 to the active site in COX1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix (Probable). COX1 is a catalytic core subunit containing heme A and the active site BNC with heme A3 and the copper atom CU(B) (PubMed:30598554).
Biological Process
Biological Process aerobic respirationManual Assertion Based On ExperimentIMP:SGD
Biological Process cellular respirationManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process electron transport coupled proton transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process mitochondrial electron transport, cytochrome c to oxygenManual Assertion Based On ExperimentIDA:SGD
Biological Process respiratory electron transport chainManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Mitochondrion inner membrane
Topology
Mitochondrial matrix: 1-14
Helical: 15-39
Mitochondrial intermembrane: 40-54
Helical: 55-88
Mitochondrial matrix: 89-97
Helical: 98-118
Mitochondrial intermembrane: 119-142
Helical: 143-171
Mitochondrial matrix: 172-183
Helical: 184-215
Mitochondrial intermembrane: 216-228
Helical: 229-263
Mitochondrial matrix: 264-269
Helical: 270-295
Mitochondrial intermembrane: 296-298
Helical: 299-327
Mitochondrial matrix: 328-335
Helical: 336-358
Mitochondrial intermembrane: 359-370
Helical: 371-400
Mitochondrial matrix: 401-406
Helical: 407-431
Mitochondrial intermembrane: 432-449
Helical: 450-474
Mitochondrial matrix: 475-534
PTM
The N-terminus is blocked.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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