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Mouse Anti-SENP2 Recombinant Antibody (CBXS-4899) (CBMAB-S2121-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4899
Antibody Isotype
IgG2b
Application
IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SUMO1/Sentrin/SMT3 Specific Peptidase 2
Introduction
SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.
Entrez Gene ID
59343
UniProt ID
Q9HC62
Alternative Names
SUMO1/Sentrin/SMT3 Specific Peptidase 2; SUMO1/Sentrin/SMT3 Specific Protease 2; Sentrin/SUMO-Specific Protease SENP2; SMT3-Specific Isopeptidase 2; SMT3IP2; AXAM2;
Function
Protease that catalyzes two essential functions in the SUMO pathway (PubMed:11896061, PubMed:12192048, PubMed:20194620, PubMed:21965678, PubMed:15296745).
The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins (PubMed:15296745).
The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein (PubMed:20194620, PubMed:21965678, PubMed:15296745).
May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway (By similarity).
Deconjugates SUMO2 from MTA1 (PubMed:21965678).
Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB (PubMed:20194620).
Acts as a regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS and STING1 during the late phase of viral infection (By similarity).
Biological Process
Biological Process fat cell differentiationISS:UniProtKB
Biological Process mRNA transportIEA:UniProtKB-KW
Biological Process negative regulation of protein ubiquitinationManual Assertion Based On ExperimentIDA:CACAO
Biological Process positive regulation of protein ubiquitinationManual Assertion Based On ExperimentIMP:CACAO
Biological Process protein destabilizationManual Assertion Based On ExperimentIMP:CACAO
Biological Process protein desumoylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein transportIEA:UniProtKB-KW
Biological Process regulation of Wnt signaling pathway1 PublicationNAS:UniProtKB
Biological Process Wnt signaling pathwayIEA:UniProtKB-KW
Cellular Location
Nucleus, nuclear pore complex
Nucleus membrane
Cytoplasm
Shuttles between cytoplasm and nucleus.
PTM
Polyubiquitinated; which leads to proteasomal degradation.
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For research use only. Not intended for any clinical use.

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