SENP2

SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.
Full Name
SUMO1/Sentrin/SMT3 Specific Peptidase 2
Function
Protease that catalyzes two essential functions in the SUMO pathway (PubMed:11896061, PubMed:12192048, PubMed:20194620, PubMed:21965678, PubMed:15296745).
The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins (PubMed:15296745).
The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein (PubMed:20194620, PubMed:21965678, PubMed:15296745).
May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway (By similarity).
Deconjugates SUMO2 from MTA1 (PubMed:21965678).
Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB (PubMed:20194620).
Acts as a regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS and STING1 during the late phase of viral infection (By similarity).
Biological Process
Biological Process fat cell differentiationISS:UniProtKB
Biological Process mRNA transportIEA:UniProtKB-KW
Biological Process negative regulation of protein ubiquitinationManual Assertion Based On ExperimentIDA:CACAO
Biological Process positive regulation of protein ubiquitinationManual Assertion Based On ExperimentIMP:CACAO
Biological Process protein destabilizationManual Assertion Based On ExperimentIMP:CACAO
Biological Process protein desumoylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein transportIEA:UniProtKB-KW
Biological Process regulation of Wnt signaling pathway1 PublicationNAS:UniProtKB
Biological Process Wnt signaling pathwayIEA:UniProtKB-KW
Cellular Location
Nucleus, nuclear pore complex
Nucleus membrane
Cytoplasm
Shuttles between cytoplasm and nucleus.
PTM
Polyubiquitinated; which leads to proteasomal degradation.
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Anti-SENP2 antibodies

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Rabbit Anti-SENP2 Recombinant Antibody (CBXS-1511) (CBMAB-S4364-CQ)

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Target: SENP2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1511
Application*: WB, P, IF
Datasheet SDS

Mouse Anti-SENP2 Recombinant Antibody (CBXS-5218) (CBMAB-S2435-CQ)

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Target: SENP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5218
Application*: F, IF, P, WB
Datasheet SDS

Mouse Anti-SENP2 Recombinant Antibody (CBXS-5188) (CBMAB-S2405-CQ)

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Target: SENP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5188
Application*: WB, F, IH
Datasheet SDS

Mouse Anti-SENP2 Recombinant Antibody (CBXS-4986) (CBMAB-S2208-CQ)

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Target: SENP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4986
Application*: WB, IF
Datasheet SDS

Mouse Anti-SENP2 Recombinant Antibody (CBXS-4899) (CBMAB-S2121-CQ)

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Target: SENP2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-4899
Application*: P, WB
Datasheet SDS

Mouse Anti-SENP2 Recombinant Antibody (CBXS-4843) (CBMAB-S2067-CQ)

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Target: SENP2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-4843
Application*: WB, F, IH, IF, P
Datasheet SDS

Mouse Anti-SENP2 (AA 139-523) Recombinant Antibody (CBXS-4510) (CBMAB-S1751-CQ)

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Target: SENP2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-4510
Application*: WB
Datasheet SDS

Mouse Anti-SENP2 Recombinant Antibody (CBXS-4212) (CBMAB-S1465-CQ)

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Target: SENP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4212
Application*: F, IF, P, WB
Datasheet SDS

Mouse Anti-SENP2 (AA 139-523) Recombinant Antibody (CBXS-4200) (CBMAB-S1453-CQ)

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Target: SENP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4200
Application*: F, WB
Datasheet SDS

Mouse Anti-SENP2 (AA 139-523) Recombinant Antibody (CBXS-4133) (CBMAB-S1387-CQ)

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Target: SENP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4133
Application*: F, IF, WB
Datasheet SDS

Mouse Anti-SENP2 Recombinant Antibody (CBXS-3989) (CBMAB-S1250-CQ)

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Target: SENP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3989
Application*: F, IF, P, WB
Datasheet SDS

Mouse Anti-SENP2 Recombinant Antibody (CBXS-3921) (CBMAB-S1189-CQ)

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Target: SENP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3921
Application*: F, IF, P, WB
Datasheet SDS

Mouse Anti-SENP2 (AA 139-523) Recombinant Antibody (CBXS-3888) (CBMAB-S1157-CQ)

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Target: SENP2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-3888
Application*: P, WB
Datasheet SDS

Mouse Anti-SENP2 Recombinant Antibody (CBXS-5749) (CBMAB-S0610-CQ)

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Target: SENP2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-5749
Application*: F, P, WB
Datasheet SDS

Mouse Anti-SENP2 Recombinant Antibody (CBXS-5629) (CBMAB-S0506-CQ)

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Target: SENP2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-5629
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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