SENP2
SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.
Full Name
SUMO1/Sentrin/SMT3 Specific Peptidase 2
Function
Protease that catalyzes two essential functions in the SUMO pathway (PubMed:11896061, PubMed:12192048, PubMed:20194620, PubMed:21965678, PubMed:15296745).
The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins (PubMed:15296745).
The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein (PubMed:20194620, PubMed:21965678, PubMed:15296745).
May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway (By similarity).
Deconjugates SUMO2 from MTA1 (PubMed:21965678).
Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB (PubMed:20194620).
Acts as a regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS and STING1 during the late phase of viral infection (By similarity).
The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins (PubMed:15296745).
The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein (PubMed:20194620, PubMed:21965678, PubMed:15296745).
May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway (By similarity).
Deconjugates SUMO2 from MTA1 (PubMed:21965678).
Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB (PubMed:20194620).
Acts as a regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS and STING1 during the late phase of viral infection (By similarity).
Biological Process
Biological Process fat cell differentiationISS:UniProtKB
Biological Process mRNA transportIEA:UniProtKB-KW
Biological Process negative regulation of protein ubiquitinationManual Assertion Based On ExperimentIDA:CACAO
Biological Process positive regulation of protein ubiquitinationManual Assertion Based On ExperimentIMP:CACAO
Biological Process protein destabilizationManual Assertion Based On ExperimentIMP:CACAO
Biological Process protein desumoylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein transportIEA:UniProtKB-KW
Biological Process regulation of Wnt signaling pathway1 PublicationNAS:UniProtKB
Biological Process Wnt signaling pathwayIEA:UniProtKB-KW
Biological Process mRNA transportIEA:UniProtKB-KW
Biological Process negative regulation of protein ubiquitinationManual Assertion Based On ExperimentIDA:CACAO
Biological Process positive regulation of protein ubiquitinationManual Assertion Based On ExperimentIMP:CACAO
Biological Process protein destabilizationManual Assertion Based On ExperimentIMP:CACAO
Biological Process protein desumoylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein transportIEA:UniProtKB-KW
Biological Process regulation of Wnt signaling pathway1 PublicationNAS:UniProtKB
Biological Process Wnt signaling pathwayIEA:UniProtKB-KW
Cellular Location
Nucleus, nuclear pore complex
Nucleus membrane
Cytoplasm
Shuttles between cytoplasm and nucleus.
Nucleus membrane
Cytoplasm
Shuttles between cytoplasm and nucleus.
PTM
Polyubiquitinated; which leads to proteasomal degradation.
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Anti-SENP2 antibodies
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CompareTarget: SENP2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1511
Application*: WB, P, IF
Target: SENP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5218
Application*: F, IF, P, WB
Target: SENP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5188
Application*: WB, F, IH
Target: SENP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4986
Application*: WB, IF
Target: SENP2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-4899
Application*: P, WB
Target: SENP2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-4843
Application*: WB, F, IH, IF, P
Target: SENP2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-4510
Application*: WB
Target: SENP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4212
Application*: F, IF, P, WB
Target: SENP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4200
Application*: F, WB
Target: SENP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4133
Application*: F, IF, WB
Target: SENP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3989
Application*: F, IF, P, WB
Target: SENP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3921
Application*: F, IF, P, WB
Target: SENP2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-3888
Application*: P, WB
Target: SENP2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-5749
Application*: F, P, WB
Target: SENP2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-5629
Application*: WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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