Human Recombinant SENP2 , Active protein, His Tag (V2LY-0526-LY6710)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins (PubMed:15296745).
The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein (PubMed:20194620, PubMed:21965678, PubMed:15296745).
May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway (By similarity).
Deconjugates SUMO2 from MTA1 (PubMed:21965678).
Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB (PubMed:20194620).
Acts as a regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS and STING1 during the late phase of viral infection (By similarity).
Biological Process mRNA transportIEA:UniProtKB-KW
Biological Process negative regulation of protein ubiquitinationManual Assertion Based On ExperimentIDA:CACAO
Biological Process positive regulation of protein ubiquitinationManual Assertion Based On ExperimentIMP:CACAO
Biological Process protein destabilizationManual Assertion Based On ExperimentIMP:CACAO
Biological Process protein desumoylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein transportIEA:UniProtKB-KW
Biological Process regulation of Wnt signaling pathway1 PublicationNAS:UniProtKB
Biological Process Wnt signaling pathwayIEA:UniProtKB-KW
Nucleus membrane
Cytoplasm
Shuttles between cytoplasm and nucleus.
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
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Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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