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Mouse Anti-SH3BGRL Recombinant Antibody (CBXS-4459) (CBMAB-S1701-CQ)

This product is a mouse antibody that recognizes SH3BGRL. The antibody CBXS-4459 can be used for immunoassay techniques such as: WB.
See all SH3BGRL antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4459
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Recombinant full length human SH3BGRL(NP_003013)
Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SH3 domain binding glutamic acid-rich protein like
Entrez Gene ID
6451
UniProt ID
O75368
Alternative Names
SH3 Domain Binding Glutamate Rich Protein Like; SH3 Domain Binding Glutamic Acid-Rich Protein Like; SH3 Domain-Binding Glutamic Acid-Rich-Like Protein; SH3-Binding Domain Glutamic Acid-Rich Protein Like; Epididymis Secretory Protein Li 115; HEL-S-115; SH3BGR;
Function
Appears to function as an adapter protein that bridges proteins together or proteins with mRNAs (PubMed:34331014).
May function as a ubiquitin ligase-substrate adapter (PubMed:34331014, PubMed:34870550).
Additionally, associates with translating cytoplasmic ribosomes and may promote the expression of specific mRNAs (PubMed:34331014, PubMed:34870550).
Biological Process
Biological Process positive regulation of cytoplasmic translational initiationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cytoplasm, cytosol
Cell membrane
Involvement in disease
Promotes breast cancer progression by enhancing the interaction between E3 ligase STUB1 and PFN1, thereby promoting proteasomal degradation of PFN1 and subsequent activation of downstream signaling pathways including PI3K/AKT, NF-kB and WNT (PubMed:34331014). Promotes autophagy presumably by stabilizing the ubuiquitin-like protein ATG12 (PubMed:34870550). Enhances mRNA translation of E3 ligase STUB1 and the autophagy-related protein PIK3C3 (PubMed:34331014, PubMed:34870550). Promotes activation and phosphorylation of ERBB2 at 'Tyr-877' and 'Tyr-1196', and prolongs localization of ERBB2 to the cell membrane (PubMed:32381043). Breast cancer patients with SH3BGRL overexpression usually experience frequent relapse and poor prognosis (PubMed:32381043, PubMed:34870550).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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