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Rabbit Anti-SKAP1 Recombinant Antibody (CBXS-1278) (CBMAB-S4137-CQ)

This product is a rabbit antibody that recognizes SKAP1. The antibody CBXS-1278 can be used for immunoassay techniques such as: WB, FC.
See all SKAP1 antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
CBXS-1278
Antibody Isotype
IgG
Application
WB, FC

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Src Kinase Associated Phosphoprotein 1
Introduction
This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins.
Entrez Gene ID
Human8631
Mouse78473
Rat286975
UniProt ID
HumanQ86WV1
MouseQ3UUV5
RatQ4V7G1
Alternative Names
Src Kinase Associated Phosphoprotein 1; Src Kinase-Associated Phosphoprotein Of 55 KDa; Src Family-Associated Phosphoprotein 1; SKAP-55; SKAP55; SCAP1;
Function
Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells.
Biological Process
Biological Process adaptive immune responseIEA:UniProtKB-KW
Biological Process positive regulation of adaptive immune responseManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of cell-cell adhesion mediated by integrinManual Assertion Based On ExperimentIGI:BHF-UCL
Biological Process positive regulation of cell-matrix adhesionManual Assertion Based On ExperimentIGI:BHF-UCL
Biological Process positive regulation of DNA-templated transcriptionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of heterotypic cell-cell adhesionManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of integrin activationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of leukocyte cell-cell adhesionManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process protein localization to plasma membraneIEA:Ensembl
Biological Process T cell receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cytoplasm
Nucleus
Cell membrane
Upon T-cell stimulation, translocates to lipid rafts at the cell membrane.
PTM
Phosphorylated on tyrosines. Phosphorylation by FYN on Tyr-271 is required for GRB2 interaction. Phosphorylation by FYN on Tyr-295 abolishes interaction with FYB1. Tyr-232 is dephosphorylated by PTPRC (Probable).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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