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Mouse Anti-SLC17A8 Recombinant Antibody (S34-34) (CBMAB-V0069-LY)

This product is antibody recognizes SLC17A8. The antibody S34-34 immunoassay techniques such as: IHC, WB.
See all SLC17A8 antibodies

Summary

Host Animal
Mouse
Specificity
Rat
Clone
S34-34
Antibody Isotype
IgG1
Application
IHC, WB

Basic Information

Immunogen
Fusion protein amino acids 546-588 (cytoplasmic C-terminus) of rat VGlut3
Specificity
Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
solute carrier family 17 member 8
Introduction
This gene encodes a vesicular glutamate transporter. The encoded protein transports the neurotransmitter glutamate into synaptic vesicles before it is released into the synaptic cleft. Mutations in this gene are the cause of autosomal-dominant nonsyndromic type 25 deafness. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Entrez Gene ID
266767
UniProt ID
Q7TSF2
Alternative Names
Vglut3
Function
Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, sodium and phosphate (PubMed:33440152, PubMed:12151341).
At the synaptic vesicle membrane, mainly functions as an uniporter that mediates the uptake of L-glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells (PubMed:12151341).
The L-glutamate uniporter activity is electrogenic and is driven by the proton electrochemical gradient, mainly by the electrical gradient established by the vacuolar H+-ATPase across the synaptic vesicle membrane (PubMed:12151341).
In addition, functions as a chloride channel that allows a chloride permeation through the synaptic vesicle membrane that affects the proton electrochemical gradient and promotes synaptic vesicles acidification (By similarity).
At the plasma membrane, following exocytosis, functions as a symporter of Na+ and phosphate from the extracellular space to the cytoplasm allowing synaptic phosphate homeostasis regulation (Probable). The symporter activity is electrogenic (PubMed:33440152).
Moreover, operates synergistically with SLC18A3/VACHT under a constant H+ gradient, thereby allowing striatal vesicular acetylcholine uptake (By similarity).
Biological Process
Biological Process anion transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process brain developmentIEA:Ensembl
Biological Process cochlea developmentIEA:Ensembl
Biological Process ion transportTAS:Reactome
Biological Process L-glutamate importISS:UniProtKB
Biological Process L-glutamate transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process neural retina developmentIEA:Ensembl
Biological Process neurotransmitter loading into synaptic vesicleManual Assertion Based On ExperimentIDA:SynGO
Biological Process phosphate ion homeostasisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of glutamate uptake involved in transmission of nerve impulseISS:UniProtKB
Biological Process regulation of acetylcholine uptakeISS:UniProtKB
Biological Process regulation of synapse structure or activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process sensory perception of soundIEA:UniProtKB-KW
Biological Process sodium-dependent phosphate transport1 PublicationIC:UniProtKB
Biological Process synaptic transmission, glutamatergicManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Cell membrane
Synapse, synaptosome
Involvement in disease
Deafness, autosomal dominant, 25 (DFNA25):
A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNA25 expression is variable in terms of onset and rate of progression, with an age-dependent penetrance resembling an early-onset presbycusis, or senile deafness, a progressive bilateral loss of hearing that occurs in the aged.
Topology
Cytoplasmic: 1-76
Helical: 77-97
Vesicular: 98-130
Helical: 131-151
Cytoplasmic: 152-153
Helical: 154-174
Vesicular: 175-182
Helical: 183-203
Cytoplasmic: 204-221
Helical: 222-242
Vesicular: 243-249
Helical: 250-270
Cytoplasmic: 271-314
Helical: 315-335
Vesicular: 336-353
Helical: 354-374
Cytoplasmic: 375-390
Helical: 391-411
Vesicular: 412-413
Helical: 414-434
Cytoplasmic: 435-447
Helical: 448-468
Vesicular: 469-481
Helical: 482-502
Cytoplasmic: 503-586
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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