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Rabbit Anti-SLC1A6 Monoclonal Antibody (EPR7742) (CBMAB-1118-YC)

Provided herein is a rabbit monoclonal antibody against Human SLC1A6. The antibody, clone EPR7742, can be used for immunoassay techniques, such as WB.
See all SLC1A6 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EPR7742
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Synthetic peptide within Human EAAT4 aa 1-100 (N terminal).
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
Introduction
SLC1A6 functions as a symporter that transports one amino acid molecule together with two or three Na+ ions and one proton, in parallel with the counter-transport of one K+ ion. SLC1A6 plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate.
Entrez Gene ID
Human6511
Mouse20513
Rat84012
UniProt ID
HumanP48664
MouseO35544
RatO35921
Alternative Names
EAAT4
Function
Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7791878, PubMed:26690923).
Functions as a symporter that transports one amino acid molecule together with two or three Na+ ions and one proton, in parallel with the counter-transport of one K+ ion. Mediates Cl- flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na+ symport (PubMed:7791878).
Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (Probable).
Biological Process
Biological Process aspartate transmembrane transportManual Assertion Based On ExperimentTAS:ProtInc
Biological Process chemical synaptic transmissionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process establishment of localization in cellIEA:Ensembl
Biological Process ion transportTAS:Reactome
Biological Process L-aspartate import across plasma membraneManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process L-glutamate import across plasma membraneManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process L-glutamate transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process neurotransmitter transportTAS:Reactome
Biological Process neurotransmitter uptakeManual Assertion Based On ExperimentIMP:SynGO
Biological Process regulation of membrane potentialIEA:Ensembl
Cellular Location
Cell membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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