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Mouse Anti-SLC22A12 Recombinant Antibody (CBXS-4400) (CBMAB-S1642-CQ)

This product is a mouse antibody that recognizes SLC22A12. The antibody CBXS-4400 can be used for immunoassay techniques such as: WB, IP, ELISA.
See all SLC22A12 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4400
Application
WB, IP, ELISA

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
solute carrier family 22 (organic anion/urate transporter), member 12
Introduction
The protein encoded by this gene is a member of the organic anion transporter (OAT) family, and it acts as a urate transporter to regulate urate levels in blood. This protein is an integral membrane protein primarily found in epithelial cells of the proximal tubule of the kidney. An elevated level of serum urate, hyperuricemia, is associated with increased incidences of gout, and mutations in this gene cause renal hypouricemia type 1. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
116085
UniProt ID
Q96S37
Alternative Names
Solute Carrier Family 22 Member 12; Solute Carrier Family 22 (Organic Anion/Cation Transporter), Member 12; Solute Carrier Family 22 (Organic Anion/Urate Transporter), Member 12; Organic Anion Transporter 4-Like Protein; Renal-Specific Transporter; Urate Anion Exchanger 1;
Function
Electroneutral antiporter that translocates urate across the apical membrane of proximal tubular cells in exchange for monovalent organic or inorganic anions (PubMed:12024214, PubMed:22194875, PubMed:35144162, PubMed:35462902).
Involved in renal reabsorption of urate and helps maintaining blood levels of uric acid (PubMed:12024214, PubMed:22194875).
Mediates urate uptake by an exchange with organic anions such as (S)-lactate and nicotinate, and inorganic anion Cl- (PubMed:12024214).
Other inorganic anions such as Br-, I- and NO3- may also act as counteranions that exchange for urate (PubMed:12024214).
Also mediates orotate tubular uptake coupled with nicotinate efflux and to a lesser extent with lactate efflux, therefore displaying a potential role in orotate renal reabsorption (PubMed:21350910).
Orotate transport is Cl--dependent (PubMed:21350910).
Biological Process
Biological Process cellular homeostasis1 PublicationNAS:UniProtKB
Biological Process cellular response to insulin stimulusIEA:Ensembl
Biological Process organic anion transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process renal urate salt excretionIEA:Ensembl
Biological Process response to xenobiotic stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process urate metabolic processManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process urate transportManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Apical cell membrane
Involvement in disease
Hypouricemia renal 1 (RHUC1):
A disorder characterized by impaired uric acid reabsorption at the apical membrane of proximal renal tubule cells, and high urinary urate excretion. Patients often appear asymptomatic, but may be subject to exercise-induced acute renal failure, chronic renal dysfunction and nephrolithiasis.
PTM
N-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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