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Mouse Anti-SLC22A6 Recombinant Antibody (1F2) (CBMAB-O0215-CQ)

This product is a mouse antibody that recognizes SLC22A6. The antibody 1F2 can be used for immunoassay techniques such as: WB, IP, IF, IHC-P, ELISA.
See all SLC22A6 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1F2
Antibody Isotype
IgG
Application
WB, IP, IF, IHC(P), ELISA

Basic Information

Immunogen
Raised against amino acids 451-550 of OAT1 of human origin
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
solute carrier family 22 (organic anion transporter), member 6
Introduction
The protein encoded by this gene is involved in the sodium-dependent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and may be localized to the basolateral membrane. Four transcript variants encoding four different isoforms have been found for this gene.
Entrez Gene ID
9356
UniProt ID
Q4U2R8
Alternative Names
Solute Carrier Family 22 Member 6; Solute Carrier Family 22 (Organic Anion Transporter), Member 6; Renal Organic Anion Transporter 1; Organic Anion Transporter 1; PAH Transporter; HROAT1; HOAT1
Function
Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the transport of prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) and may be involved in their renal excretion (PubMed:11907186).
Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS) (By similarity).
Also mediates the sodium-independent uptake of p-aminohippurate (PAH), ochratoxin (OTA), acyclovir (ACV), 3'-azido-3-'deoxythymidine (AZT), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) and 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF), cidofovir, adefovir, 9-(2-phosphonylmethoxyethyl) guanine (PMEG), 9-(2-phosphonylmethoxyethyl) diaminopurine (PMEDAP) and edaravone sulfate. PAH uptake is inhibited by p-chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), sulindac, diclofenac, carprofen, glutarate and okadaic acid (By similarity).
PAH uptake is inhibited by benzothiazolylcysteine (BTC), S-chlorotrifluoroethylcysteine (CTFC), cysteine S-conjugates S-dichlorovinylcysteine (DCVC), furosemide, steviol, phorbol 12-myristate 13-acetate (PMA), calcium ionophore A23187, benzylpenicillin, furosemide, indomethacin, bumetamide, losartan, probenecid, phenol red, urate, and alpha-ketoglutarate.
Biological Process
Biological Process alpha-ketoglutarate transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process organic anion transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process renal tubular secretionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process response to organic cyclic compoundIEA:Ensembl
Biological Process sodium-independent organic anion transportIDA:UniProtKB
Cellular Location
Cell membrane
PTM
Glycosylated. Glycosylation at Asn-113 may occur at a secondary level. Glycosylation is necessary for proper targeting of the transporter to the plasma membrane.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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