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Mouse Anti-SLC6A5 Recombinant Antibody (CBXS-3022) (CBMAB-S5768-CQ)

This product is a mouse antibody that recognizes SLC6A5. The antibody CBXS-3022 can be used for immunoassay techniques such as: ELISA, WB.
See all SLC6A5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-3022
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa294-394 from SLC6A5 (NP_004202) with GST tag
Specificity
Human
Antibody Isotype
IgG1, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
solute carrier family 6 (neurotransmitter transporter, glycine), member 5
Introduction
This gene encodes a sodium- and chloride-dependent glycine neurotransmitter transporter. This integral membrane glycoprotein is responsible for the clearance of extracellular glycine during glycine-mediated neurotransmission. This protein is found in glycinergic axons and maintains a high presynaptic pool of neurotransmitter at glycinergic synapses. Mutations in this gene cause hyperekplexia; a heterogenous neurological disorder characterized by exaggerated startle responses and neonatal apnea. Two transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
9152
UniProt ID
Q9Y345
Alternative Names
Solute Carrier Family 6 Member 5; Solute Carrier Family 6 (Neurotransmitter Transporter, Glycine), Member 5; GLYT-2; GLYT2; NET1; Solute Carrier Family 6 (Neurotransmitter Transporter), Member 5; Sodium- And Chloride-Dependent Glycine Transporter 2; Glycine Transporter 2; HKPX3;
Function
Sodium- and chloride-dependent glycine transporter (PubMed:9845349, PubMed:10381548, PubMed:10606742, PubMed:31370103, PubMed:16751771).
Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals (PubMed:9845349).
May be responsible for the termination of neurotransmission at strychnine-sensitive glycinergic synapses (PubMed:9845349).
Isoform 2
Lacks sodium- and chloride-dependent glycine transporter activity.
Isoform 3
Lacks sodium- and chloride-dependent glycine transporter activity.
Biological Process
Biological Process chemical synaptic transmissionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process glycine import across plasma membraneManual Assertion Based On ExperimentIDA:FlyBase
Biological Process neurotransmitter uptakeIEA:Ensembl
Biological Process sodium ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process synaptic transmission, glycinergicManual Assertion Based On ExperimentIMP:FlyBase
Cellular Location
Cell membrane
Involvement in disease
Hyperekplexia 3 (HKPX3):
A neurologic disorder characterized by neonatal hypertonia, an exaggerated startle response to tactile or acoustic stimuli, and life-threatening neonatal apnea episodes. Notably, in some cases, symptoms resolved in the first year of life.
PTM
N-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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