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Rabbit Anti-SRSF3 Recombinant Antibody (CBXS-1430) (CBMAB-S4288-CQ)

This product is a rabbit antibody that recognizes SRSF3. The antibody CBXS-1430 can be used for immunoassay techniques such as: WB, IHC-P, FC, IF.
See all SRSF3 antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
CBXS-1430
Antibody Isotype
IgG
Application
WB, IHC-P, FC, IF

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
serine and arginine rich splicing factor 3
Introduction
The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants, one protein-coding and the other non-coding, have been found for this gene.
Entrez Gene ID
Human6428
Mouse20383
Rat361814
UniProt ID
HumanP84103
MouseP84104
RatQ0ZFS8
Alternative Names
Serine And Arginine Rich Splicing Factor 3; Splicing Factor, Arginine/Serine-Rich 3; Serine/Arginine-Rich Splicing Factor 3; Pre-MRNA-Splicing Factor SRP20; SRp20; SFRS3; Splicing Factor, Arginine/Serine-Rich, 20-KD; Pre-MRNA Splicing Factor SRp20;
Function
Splicing factor that specifically promotes exon-inclusion during alternative splicing (PubMed:26876937).
Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937).
Also functions as export adapter involved in mRNA nuclear export (PubMed:11336712, PubMed:18364396, PubMed:28984244).
Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity (PubMed:11336712, PubMed:18364396).
Involved in nuclear export of m6A-containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244).
RNA-binding is semi-sequence specific (PubMed:17036044).
Biological Process
Biological Process cellular response to leukemia inhibitory factorIEA:Ensembl
Biological Process mRNA export from nucleusManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIBA:GO_Central
Biological Process primary miRNA processingManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process regulation of mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Nucleus
Nucleus speckle
Cytoplasm
Recruited to nuclear speckles following interaction with YTHDC1.
PTM
Phosphorylated by CLK1, CLK2, CLK3 and CLK4. Extensively phosphorylated on serine residues in the RS domain.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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