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Rabbit Anti-SYN2 Monoclonal Antibody (EPR3277) (CBMAB-1581-YC)

Provided herein is a rabbit monoclonal antibody against Human SYN2. The antibody, clone EPR3277, can be used for immunoassay techniques, such as IHC-P and WB.
See all SYN2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EPR3277
Antibody Isotype
IgG
Application
IHC-P, WB

Basic Information

Immunogen
Synthetic human peptide
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Synapsin II
Introduction
SYN2 is a member of the synapsin gene family. Polymorphisms in SYN2 are associated with abnormal presynaptic function and related neuronal disorders, including autism, epilepsy, bipolar disorder and schizophrenia.
Entrez Gene ID
Human6853
Mouse20965
Rat29179
UniProt ID
HumanQ92777
MouseQ64332
RatP09951
Alternative Names
synapsin-2
Function
Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. May play a role in noradrenaline secretion by sympathetic neurons (By similarity).
Biological Process
Biological Process calcium-ion regulated exocytosisIEA:Ensembl
Biological Process chemical synaptic transmissionTAS:ProtInc1 Publication
Biological Process neurotransmitter secretionISS:ParkinsonsUK-UCL
Biological Process synaptic vesicle clusteringIEA:Ensembl
Cellular Location
Synapse
Involvement in disease
Schizophrenia (SCZD):
A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder.
PTM
Phosphorylation at Ser-10 dissociates synapsins from synaptic vesicles. Phosphorylation at Ser-425 by MAPK1/ERK2 and/or MAPK3/ERK1 may play a role in noradrenaline secretion by sympathetic neurons (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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