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Rabbit Anti-SYNE3 Recombinant Antibody (CBWJN-1685) (CBMAB-N4320-WJ)

This product is a Rabbit antibody that recognizes SYNE3. The antibody CBWJN-1685 can be used for immunoassay techniques such as: WB.
See all SYNE3 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBWJN-1685
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1.137 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
spectrin repeat containing, nuclear envelope family member 3
Introduction
SYNE3 (Spectrin Repeat Containing Nuclear Envelope Family Member 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include actin binding and actin filament binding.
Entrez Gene ID
161176
UniProt ID
Q6ZMZ3
Alternative Names
KASH3; NET53; Nesp3; C14orf49; C14orf139; LINC00341; NCRNA00341
Function
As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells.
Biological Process
Biological Process cytoskeleton organizationIMP:UniProtKB1 Publication
Biological Process establishment of protein localization to membraneIDA:UniProtKB1 Publication
Biological Process nuclear migrationIBA:GO_Central1 Publication
Biological Process regulation of cell shapeIMP:UniProtKB1 Publication
Topology
Cytoplasmic: 1-925
Helical: 926-946
Perinuclear space: 947-975
PTM
The disulfid bond with SUN1 or SUN2 is required for stability of the respective LINC complex under tensile forces.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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