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Rat Anti-TDGF1 Recombinant Antibody (CBFYC-0460) (CBMAB-C0506-FY)

This product is rat antibody that recognizes TDGF1. The antibody CBFYC-0460 can be used for immunoassay techniques such as: FC.
See all TDGF1 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBFYC-0460
Antibody Isotype
IgG2b
Application
FC

Basic Information

Specificity
Mouse
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.2 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TDGF1 Gene(Protein Coding) Teratocarcinoma-Derived Growth Factor 1
Introduction
This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants.
Entrez Gene ID
21667
UniProt ID
Q7TQ06
Alternative Names
CR1; cripto; teratocarcinoma-derived growth factor; TERATOCARCINOMA-DERIVED GROWTH FACTOR PRECURSOR (EPIDERMAL GROWTH FACTOR-LIKE CRIPTO PROTEIN) (CRIPTO GROWTH FACTOR); cripto growth factor; epidermal growth factor-like Cripto protein
Function
GPI-anchored cell membrane protein involved in Nodal signaling. Cell-associated TDGF1 acts as a Nodal coreceptor in cis. Shedding of TDGF1 by TMEM8A modulates Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells (PubMed:27881714).
Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm (PubMed:11909953).
Biological Process
Biological Process anatomical structure developmentIBA:GO_Central1 Publication
Biological Process anterior/posterior axis specification, embryoISS:UniProtKB
Biological Process anterior/posterior pattern specificationIBA:GO_Central1 Publication
Biological Process blood vessel developmentIBA:GO_Central1 Publication
Biological Process cell differentiationTAS:UniProtKB1 Publication
Biological Process cell migration involved in sprouting angiogenesisIMP:UniProtKB1 Publication
Biological Process cellular response to epidermal growth factor stimulusIDA:UniProtKB1 Publication
Biological Process cellular response to fibroblast growth factor stimulusIDA:UniProtKB1 Publication
Biological Process cellular response to hepatocyte growth factor stimulusIDA:UniProtKB1 Publication
Biological Process cellular response to interferon-gammaIDA:UniProtKB1 Publication
Biological Process cellular response to interleukin-6IDA:UniProtKB1 Publication
Biological Process cellular response to tumor necrosis factorIDA:UniProtKB1 Publication
Biological Process determination of left/right symmetryIBA:GO_Central1 Publication
Biological Process embryo development ending in birth or egg hatchingTAS:UniProtKB1 Publication
Biological Process heart developmentIDA:UniProtKB1 Publication
Biological Process mammary gland developmentTAS:UniProtKB1 Publication
Biological Process morphogenesis of a branching structureTAS:UniProtKB1 Publication
Biological Process negative regulation of apoptotic processIDA:UniProtKB1 Publication
Biological Process nodal signaling pathwayIBA:GO_Central1 Publication
Biological Process peptidyl-serine phosphorylationIDA:UniProtKB1 Publication
Biological Process positive regulation of cell migrationIDA:UniProtKB1 Publication
Biological Process positive regulation of cell population proliferationIDA:MGI1 Publication
Biological Process positive regulation of endothelial cell migrationIDA:UniProtKB1 Publication
Biological Process positive regulation of MAP kinase activityIDA:MGI1 Publication
Biological Process positive regulation of MAPK cascadeIDA:UniProtKB1 Publication
Biological Process positive regulation of peptidyl-tyrosine phosphorylationIDA:UniProtKB1 Publication
Biological Process regulation of signal transductionIDA:UniProtKB1 Publication
Cellular Location
Cell membrane
Secreted
Released from the cell membrane by GPI cleavage.
PTM
The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, it is processed by GPI processing phospholipase A2 (TMEM8A), removing an acyl-chain at the sn-2 position of GPI and releasing TDGF1 as a lysophosphatidylinositol-bearing form, which is further cleaved by phospholipase D (GPLD1) into a soluble form.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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