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Mouse Anti-TDGF1 Recombinant Antibody (1F10) (CBMAB-C0519-LY)

This product is antibody recognizes TDGF1. The antibody 1F10 immunoassay techniques such as: WB, IHC-P, IF(IHC-P).
See all TDGF1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1F10
Antibody Isotype
IgG
Application
WB, IHC-P, IF(IHC-P)

Basic Information

Immunogen
KLH conjugated peptide, human CRIPTO/ Teratocarcinoma-derived growth factor 1
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
TDGF1 Gene(Protein Coding) Teratocarcinoma-Derived Growth Factor 1
Introduction
This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Entrez Gene ID
6997
UniProt ID
P13385
Alternative Names
Teratocarcinoma-Derived Growth Factor 1; Epidermal Growth Factor-Like Cripto Protein CR1; Cripto-1 Growth Factor; CRIPTO; CRGF; CR;
Function
GPI-anchored cell membrane protein involved in Nodal signaling. Cell-associated TDGF1 acts as a Nodal coreceptor in cis. Shedding of TDGF1 by TMEM8A modulates Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells (PubMed:27881714).
Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm (PubMed:11909953).
Biological Process
Biological Process anatomical structure developmentIBA:GO_Central1 Publication
Biological Process anterior/posterior axis specification, embryoISS:UniProtKB
Biological Process anterior/posterior pattern specificationIBA:GO_Central1 Publication
Biological Process blood vessel developmentIBA:GO_Central1 Publication
Biological Process cell differentiationTAS:UniProtKB1 Publication
Biological Process cell migration involved in sprouting angiogenesisIMP:UniProtKB1 Publication
Biological Process cellular response to epidermal growth factor stimulusIDA:UniProtKB1 Publication
Biological Process cellular response to fibroblast growth factor stimulusIDA:UniProtKB1 Publication
Biological Process cellular response to hepatocyte growth factor stimulusIDA:UniProtKB1 Publication
Biological Process cellular response to interferon-gammaIDA:UniProtKB1 Publication
Biological Process cellular response to interleukin-6IDA:UniProtKB1 Publication
Biological Process cellular response to tumor necrosis factorIDA:UniProtKB1 Publication
Biological Process determination of left/right symmetryIBA:GO_Central1 Publication
Biological Process embryo development ending in birth or egg hatchingTAS:UniProtKB1 Publication
Biological Process heart developmentIDA:UniProtKB1 Publication
Biological Process mammary gland developmentTAS:UniProtKB1 Publication
Biological Process morphogenesis of a branching structureTAS:UniProtKB1 Publication
Biological Process negative regulation of apoptotic processIDA:UniProtKB1 Publication
Biological Process nodal signaling pathwayIBA:GO_Central1 Publication
Biological Process peptidyl-serine phosphorylationIDA:UniProtKB1 Publication
Biological Process positive regulation of cell migrationIDA:UniProtKB1 Publication
Biological Process positive regulation of cell population proliferationIDA:MGI1 Publication
Biological Process positive regulation of endothelial cell migrationIDA:UniProtKB1 Publication
Biological Process positive regulation of MAP kinase activityIDA:MGI1 Publication
Biological Process positive regulation of MAPK cascadeIDA:UniProtKB1 Publication
Biological Process positive regulation of peptidyl-tyrosine phosphorylationIDA:UniProtKB1 Publication
Biological Process regulation of signal transductionIDA:UniProtKB1 Publication
Cellular Location
Cell membrane
Secreted
Released from the cell membrane by GPI cleavage.
PTM
The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, it is processed by GPI processing phospholipase A2 (TMEM8A), removing an acyl-chain at the sn-2 position of GPI and releasing TDGF1 as a lysophosphatidylinositol-bearing form, which is further cleaved by phospholipase D (GPLD1) into a soluble form.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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