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Mouse Anti-TIE1 Recombinant Antibody (8C9) (CBMAB-T2401-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
8C9
Antibody Isotype
IgG1
Application
WB, ELISA

Basic Information

Immunogen
Recombinant human soluble TIE-1 protein
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TIE1 Gene(Protein Coding) Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains 1
Introduction
TIE1 is a member of the tyrosine protein kinase family. TIE1 plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor.
Entrez Gene ID
7075
UniProt ID
P35590
Alternative Names
Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains 1; Tyrosine Kinase With Immunoglobulin And Epidermal Growth Factor Homology Domains 1; EC 2.7.10.1; TIE; Tyrosine Kinase With Immunoglobulin-Like And EGF-Like Domains 1; Tyrosine-Protein Kinase Receptor Tie-1; EC 2.7.10; JTK14
Function
Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis.
Biological Process
Biological Process angiogenesisSource:UniProtKB-KW
Biological Process aortic valve morphogenesisSource:BHF-UCL
Biological Process branching involved in lymph vessel morphogenesisSource:BHF-UCL
Biological Process in utero embryonic developmentSource:Ensembl
Biological Process lymphatic endothelial cell differentiationSource:BHF-UCL
Biological Process mesoderm developmentSource:ProtInc1 Publication
Biological Process negative regulation of angiogenesisSource:Ensembl
Biological Process negative regulation of cell migrationSource:Ensembl
Biological Process plasma membrane fusionSource:Ensembl
Biological Process positive regulation of angiogenesisSource:GO_Central1 Publication
Biological Process positive regulation of kinase activitySource:GO_Central1 Publication
Biological Process regulation of endothelial cell proliferationSource:BHF-UCL
Biological Process regulation of extracellular matrix assemblySource:BHF-UCL
Biological Process response to retinoic acidSource:Ensembl
Biological Process signal transductionSource:ProtInc1 Publication
Biological Process tissue remodelingSource:BHF-UCL
Biological Process transmembrane receptor protein tyrosine kinase signaling pathwaySource:GO_Central1 Publication
Biological Process vasculogenesisSource:Ensembl
Cellular Location
Cell membrane
Involvement in disease
Lymphatic malformation 11 (LMPHM11):
A form of primary lymphedema, a disease characterized by swelling of body parts due to developmental anomalies and functional defects of the lymphatic system. Patients with lymphedema may suffer from recurrent local infections. LMPHM11 is an autosomal dominant form characterized by onset of lower extremity edema in the second or third decade of life. Some affected individuals may have subclinical lymphatic malformations.
Topology
Extracellular: 22-759
Helical: 760-784
Cytoplasmic: 785-1138
PTM
Phosphorylated on tyrosine residues in response to ANGPT1, most likely by TEK/TIE2.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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