TIE1

This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

TIE1 Gene(Protein Coding) Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains 1

Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis.

Biological Process angiogenesisSource:UniProtKB-KW
Biological Process aortic valve morphogenesisSource:BHF-UCL
Biological Process branching involved in lymph vessel morphogenesisSource:BHF-UCL
Biological Process in utero embryonic developmentSource:Ensembl
Biological Process lymphatic endothelial cell differentiationSource:BHF-UCL
Biological Process mesoderm developmentSource:ProtInc1 Publication
Biological Process negative regulation of angiogenesisSource:Ensembl
Biological Process negative regulation of cell migrationSource:Ensembl
Biological Process plasma membrane fusionSource:Ensembl
Biological Process positive regulation of angiogenesisSource:GO_Central1 Publication
Biological Process positive regulation of kinase activitySource:GO_Central1 Publication
Biological Process regulation of endothelial cell proliferationSource:BHF-UCL
Biological Process regulation of extracellular matrix assemblySource:BHF-UCL
Biological Process response to retinoic acidSource:Ensembl
Biological Process signal transductionSource:ProtInc1 Publication
Biological Process tissue remodelingSource:BHF-UCL
Biological Process transmembrane receptor protein tyrosine kinase signaling pathwaySource:GO_Central1 Publication
Biological Process vasculogenesisSource:Ensembl

Cell membrane

Lymphatic malformation 11 (LMPHM11):
A form of primary lymphedema, a disease characterized by swelling of body parts due to developmental anomalies and functional defects of the lymphatic system. Patients with lymphedema may suffer from recurrent local infections. LMPHM11 is an autosomal dominant form characterized by onset of lower extremity edema in the second or third decade of life. Some affected individuals may have subclinical lymphatic malformations.

Extracellular: 22-759
Helical: 760-784
Cytoplasmic: 785-1138

Phosphorylated on tyrosine residues in response to ANGPT1, most likely by TEK/TIE2.