Human Recombinant TIE1 protein, His Tag (V2LY-0526-LY7200)

Name: Human Recombinant TIE1 protein, His Tag
SKU: V2LY-0526-LY7200
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant TIE1 protein, His Tag consist of Amino Acid: 1-760 and predicts a molecular mass of 81.4 kDa.

Molecule Mass

81.4 kDa

Sequence

Amino Acid: 1-760

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>90% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

TIE1 Gene(Protein Coding) Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains 1

Function

Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis.

Biological Process

Biological Process angiogenesisSource:UniProtKB-KW
Biological Process aortic valve morphogenesisSource:BHF-UCL
Biological Process branching involved in lymph vessel morphogenesisSource:BHF-UCL
Biological Process in utero embryonic developmentSource:Ensembl
Biological Process lymphatic endothelial cell differentiationSource:BHF-UCL
Biological Process mesoderm developmentSource:ProtInc1 Publication
Biological Process negative regulation of angiogenesisSource:Ensembl
Biological Process negative regulation of cell migrationSource:Ensembl
Biological Process plasma membrane fusionSource:Ensembl
Biological Process positive regulation of angiogenesisSource:GO_Central1 Publication
Biological Process positive regulation of kinase activitySource:GO_Central1 Publication
Biological Process regulation of endothelial cell proliferationSource:BHF-UCL
Biological Process regulation of extracellular matrix assemblySource:BHF-UCL
Biological Process response to retinoic acidSource:Ensembl
Biological Process signal transductionSource:ProtInc1 Publication
Biological Process tissue remodelingSource:BHF-UCL
Biological Process transmembrane receptor protein tyrosine kinase signaling pathwaySource:GO_Central1 Publication
Biological Process vasculogenesisSource:Ensembl

Cellular Location

Cell membrane

Involvement in disease

Lymphatic malformation 11 (LMPHM11):
A form of primary lymphedema, a disease characterized by swelling of body parts due to developmental anomalies and functional defects of the lymphatic system. Patients with lymphedema may suffer from recurrent local infections. LMPHM11 is an autosomal dominant form characterized by onset of lower extremity edema in the second or third decade of life. Some affected individuals may have subclinical lymphatic malformations.

Topology

Extracellular: 22-759
Helical: 760-784
Cytoplasmic: 785-1138

PTM

Phosphorylated on tyrosine residues in response to ANGPT1, most likely by TEK/TIE2.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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