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Rabbit Anti-TJP3 Recombinant Antibody (CBWJZ-275) (CBMAB-Z0711-WJ)

This product is a rabbit antibody that recognizes TJP3. The antibody CBWJZ-275 can be used for immunoassay techniques such as: ICC, ELISA, WB.
See all TJP3 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBWJZ-275
Antibody Isotype
IgG
Application
ICC, ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.5 mg/mL

Target

Full Name
TJP3 Gene(Protein Coding) Tight Junction Protein 3
Introduction
The protein encoded by this gene is a member of the membrane-associated guanylate kinase-like (MAGUK) protein family which is characterized by members having multiple PDZ domains, a single SH3 domain, and a single guanylate kinase-like (GUK)-domain. In addition, members of the zonula occludens protein subfamily have an acidic domain, a basic arginine-rich region, and a proline-rich domain. The protein encoded by this gene plays a role in the linkage between the actin cytoskeleton and tight-junctions and also sequesters cyclin D1 at tight junctions during mitosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. This gene has a partial pseudogene on chromosome 1.
Entrez Gene ID
27134
UniProt ID
O95049
Alternative Names
ZO3; ZO-3
Function
TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:16129888).
The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Binds and recruits PATJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions (PubMed:16129888).
Promotes cell-cycle progression through the sequestration of cyclin D1 (CCND1) at tight junctions during mitosis which prevents CCND1 degradation during M-phase and enables S-phase transition (PubMed:21411630).
With TJP1 and TJP2, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity).
Contrary to TJP2, TJP3 is dispensable for individual viability, embryonic development, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment (By similarity).
Biological Process
Biological Process cell-cell adhesionSource:GO_Central1 Publication
Biological Process cell-cell junction organizationSource:GO_Central1 Publication
Biological Process establishment of endothelial intestinal barrierSource:GO_Central1 Publication
Biological Process maintenance of blood-brain barrierSource:ARUK-UCL1 Publication
Biological Process positive regulation of blood-brain barrier permeabilitySource:GO_Central1 Publication
Biological Process protein localization to cell-cell junctionSource:GO_Central1 Publication
PTM
Phosphorylated (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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