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Mouse Anti-TM4SF20 Recombinant Antibody (CBYJT-3448) (CBMAB-T2770-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TM4SF20 (Transmembrane 4 L Six Family Member 20). The antibody can be used for immunoassay techniques, such as FC.
See all TM4SF20 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-3448
Antibody Isotype
IgG1, κ
Application
FC

Basic Information

Immunogen
Human TM4SF20-transfected cells
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2, 0.2% BSA
Preservative
0.09% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Transmembrane 4 L Six Family Member 20
Introduction
TM4SF20 is a member of the four-transmembrane L6 superfamily. Members of this family function in various cellular processes including cell proliferation, motility, and adhesion via their interactions with integrins. In human brain tissue, this gene is expressed at high levels in the parietal lobe, occipital lobe, hippocampus, pons, white matter, corpus callosum, and cerebellum. Knockout of the homologous gene in mouse results in a neurobehavioral phenotype with suggested enhanced motor coordination. A deletion mutation in the human gene is associated with specific language impairment-5.
Entrez Gene ID
79853
UniProt ID
Q53R12
Alternative Names
Transmembrane 4 L Six Family Member 20; Transmembrane 4 L6 Family Member 20; TCCE518; PRO994; SLI5
Function
Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis (PubMed:25310401, PubMed:27499293).
In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1 (PubMed:27499293).
Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called 'regulated alternative translocation' (RAT) and regulates the function of the transmembrane protein (PubMed:27499293).
Biological Process
Negative regulation of proteolysis
Cellular Location
Membrane
Endoplasmic reticulum membrane
Ceramide alters the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20.
Involvement in disease
Specific language impairment 5 (SLI5):
A disorder characterized by a delay in early speech acquisition. It is usually associated with cerebral white matter abnormalities on brain MRI. Some individuals may show disorders in communication, consistent with autism spectrum disorder, or global developmental delay, although others ultimately show normal cognitive function. Penetrance is incomplete and expressivity is variable.
Topology
Lumenal: 1-14
Helical: 15-35
Cytoplasmic: 36-44
Helical: 45-65
Lumenal: 66-83
Helical: 84-104
Cytoplasmic: 105-185
Helical: 186-206
Lumenal: 207-229
PTM
Glycosylated at Asn-132, Asn-148 and Asn-163 in presence of ceramide which inverts the orientation of TM4SF20 in membranes exposing these residues to the endoplasmic reticulum lumen.
Cleaved by signal peptidase at Ser-14 but the peptide does not act as a signal peptide. Cleavage is inhibited by ceramide which inverts the orientation of TM4SF20 in membranes exposing the N-terminus to the cytosol and not to the endoplasmic reticulum lumen.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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