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Mouse Anti-TMEM123 Recombinant Antibody (CBYC-P847) (CBMAB-P3712-YC)

Provided herein is a Mouse monoclonal antibody against Human Transmembrane Protein 123. The antibody can be used for immunoassay techniques, such as FC.
See all TMEM123 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYC-P847
Antibody Isotype
IgG2b
Application
FC

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
transmembrane protein 123
Introduction
TMEM123 is a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death.
Entrez Gene ID
114908
UniProt ID
Q8N131
Alternative Names
KCT3; PORIMIN; PORMIN
Function
Implicated in oncotic cell death, characterized by cell swelling, organelle swelling, vacuolization and increased membrane permeability.
Biological Process
Oncosis
Cellular Location
Membrane
Topology
Extracellular: 27-166
Helical: 167-187
Cytoplasmic: 188-208
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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