TMEM123 (NP_443164, 34 a.a. ~ 133 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: ETLQHVPSDH TNETSNSTVK PPTSVASDSS NTTVTTMKPT AASNTTTPGM VSTNMTSTTL KSTPKTTSVS QNTSQISTST MTVTHNSSVT SAASSVTITT
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
TMEM123 is a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. TMEM123 is proposed to play a role as a cell surface receptor that mediates cell death.
Transmembrane Protein 123; Pro-Oncosis Receptor Inducing Membrane Injury; KCT-3; KCT3; Pro Oncosis Receptor Inducing Membrane Injury Gene; Keratinocytes Associated Transmembrane Protein 3