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Mouse Anti-TNKS2 Recombinant Antibody (CBYC-P849) (CBMAB-P3715-YC)

Provided herein is a Mouse monoclonal antibody against Human Tankyrase 2. The antibody can be used for immunoassay techniques, such as WB, ICC, IHC-P, IHC-Fr, ELISA.
See all TNKS2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYC-P849
Antibody Isotype
IgG
Application
WB, ICC, IHC-P, IHC-Fr, ELISA

Basic Information

Immunogen
Tankyrase 2
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.4, 0.02% sodium azide, 50% glycerol
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Tankyrase 2
Introduction
TNKS2 (Tankyrase 2) is a protein coding gene. Among its related pathways are Metabolism of proteins and Telomere Extension by Telomerase. Gene Ontology annotations related to this gene include enzyme binding and NAD+ ADP-ribosyltransferase activity. An important paralog of the gene is TNKS.
Entrez Gene ID
80351
UniProt ID
Q9H2K2
Alternative Names
ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C; TANK2; TNKL; pART6
Function
Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking (PubMed:11739745, PubMed:11802774, PubMed:19759537, PubMed:21478859, PubMed:23622245, PubMed:25043379).
Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation (PubMed:19759537, PubMed:21478859).
Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination (PubMed:21478859).
Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length (PubMed:11739745).
Stimulates 26S proteasome activity (PubMed:23622245).
Biological Process
Biological Process multicellular organism growth Source:Ensembl
Biological Process negative regulation of telomere maintenance via telomere lengthening Source:BHF-UCL1 Publication
Biological Process positive regulation of canonical Wnt signaling pathway Source:UniProtKB1 Publication
Biological Process positive regulation of telomere capping Source:BHF-UCL1 Publication
Biological Process positive regulation of telomere maintenance via telomerase Source:BHF-UCL1 Publication
Biological Process protein ADP-ribosylation Source:BHF-UCL1 Publication
Biological Process protein auto-ADP-ribosylation Source:UniProtKB2 Publications
Biological Process protein localization to chromosome, telomeric region Source:BHF-UCL1 Publication
Biological Process protein poly-ADP-ribosylation Source:UniProtKB1 Publication
Biological Process protein polyubiquitination Source:UniProtKB2 Publications
Biological Process regulation of multicellular organism growth Source:Ensembl
Biological Process Wnt signaling pathway Source:UniProtKB-KW
Cellular Location
Cytoplasm
Golgi apparatus membrane
Nucleus
Chromosome, telomere
Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. Also found around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS2 is found in the nucleus, associated with TRF1.
PTM
Ubiquitinated at 'Lys-48' and 'Lys-63' by RNF146 when auto-poly-ADP-ribosylated; this leads to degradation.
ADP-ribosylated (-auto). Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination.
The crystallographic evidence suggests that the 3-hydroxyhistidine may be the (3S) stereoisomer.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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