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Mouse Anti-TRBC1 Recombinant Antibody (CBYJT-4580) (CBMAB-T4097-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TRBC1 (T Cell Receptor Beta Constant 1). The antibody can be used for immunoassay techniques, such as FC.
See all TRBC1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-4580
Antibody Isotype
IgG1
Application
FC

Basic Information

Immunogen
Human TCR alpha/beta
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2, 0.2% BSA
Preservative
0.09% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
T Cell Receptor Beta Constant 1
Introduction
TRBC1 (T Cell Receptor Beta Constant 1) is a Protein Coding gene. Among its related pathways are Innate Immune System and Translocation of ZAP-70 to Immunological synapse. An important paralog of TRBC1 is TRBC2.
Entrez Gene ID
28639
UniProt ID
P01850
Alternative Names
T Cell Receptor Beta Constant 1; V_segment Translation Product; BV05S1J2.2; TCRBC1; TCRB
Function
Constant region of T cell receptor (TR) beta chain (PubMed:24600447).
Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333).
Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:9382891, PubMed:23524462).
The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).
Biological Process
Biological Process adaptive immune response Source:ComplexPortal1 Publication
Biological Process alpha-beta T cell activation Source:ComplexPortal1 Publication
Biological Process B cell receptor signaling pathway Source:GO_Central1 Publication
Biological Process complement activation, classical pathway Source:GO_Central1 Publication
Biological Process defense response to bacterium Source:GO_Central1 Publication
Biological Process immune response Source:UniProtKB1 Publication
Biological Process innate immune response Source:GO_Central1 Publication
Biological Process phagocytosis, engulfment Source:GO_Central1 Publication
Biological Process phagocytosis, recognition Source:GO_Central1 Publication
Biological Process positive regulation of B cell activation Source:GO_Central1 Publication
Biological Process T cell receptor signaling pathway Source:ComplexPortal1 Publication
Cellular Location
Cell membrane
Topology
Helical: 150-170
Cytoplasmic: 171-176
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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