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Mouse Anti-TRBV16 Recombinant Antibody (CBYJT-4582) (CBMAB-T4099-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TRBV16 (T Cell Receptor Beta Variable 16 (Gene/Pseudogene)). The antibody can be used for immunoassay techniques, such as FC, ICC, IF, IHC, IHC-P, IP, WB.
See all TRBV16 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CBYJT-4582
Antibody Isotype
IgG1
Application
FC, ICC, IF, IHC, IHC-P, IP, WB

Basic Information

Specificity
Human, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, 0.5% BSA
Preservative
0.1% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
T Cell Receptor Beta Variable 16 (Gene/Pseudogene)
Introduction
TRBV16 (T Cell Receptor Beta Variable 16 (Gene/Pseudogene)) is a Pseudogene. An important paralog of TRBV16 is TRBV23-1.
Entrez Gene ID
Human28571
Mouse100124680
UniProt ID
HumanA0A087WV62
MouseA0A0B4J1H3
Alternative Names
T Cell Receptor Beta Variable 16 (Gene/Pseudogene); T-Cell Receptor Beta Chain V Region; T Cell Receptor Beta Variable 16; TCRBV25S1A2PT; BV25S1J1.2; TCRBV16S1; TCRBV25S1; TCRB
Function
V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447).
Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333).
Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462).
The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).
Biological Process
Biological Process adaptive immune response Source:UniProtKB-KW
Biological Process cell surface receptor signaling pathway Source:GO_Central1 Publication
Cellular Location
Cell membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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