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Mouse Anti-TSNAX Recombinant Antibody (CBYJT-5060) (CBMAB-T4637-YJ)


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Summary

Host Animal
Mouse
Specificity
Human, Rat, Mouse
Clone
CBYJT-5060
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 1-290 representing full length TRAX of human origin
Specificity
Human, Rat, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-290

Target

Full Name
Translin Associated Factor X
Introduction
TSNAX is a protein which specifically interacts with translin, a DNA-binding protein that binds consensus sequences at breakpoint junctions of chromosomal translocations. TSNAX contains bipartite nuclear targeting sequences that may provide nuclear transport for translin, which lacks any nuclear targeting motifs.
Entrez Gene ID
Human7257
Mouse53424
Rat64028
UniProt ID
HumanQ99598
MouseQ9QZE7
RatQ9JHB5
Alternative Names
Translin Associated Factor X; TRAX; Translin-Associated Protein X; Translin-Associated Factor X; Translin-Like Protein
Function
Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis.
Biological Process
Biological Process cell differentiation Source:UniProtKB-KW
Biological Process siRNA processing Source:ComplexPortal1 Publication
Biological Process spermatogenesis Source:UniProtKB-KW
Cellular Location
Cytoplasm, perinuclear region
Golgi apparatus
Nucleus
Accumulate in the Golgi complex of mid-late pachytene spermatocytes (By similarity).
Expressed in the cytoplasm in the presence of TSN
PTM
Sumoylated with SUMO1.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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