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Mouse Anti-TWIST2 Recombinant Antibody (CBYJT-5418) (CBMAB-T5024-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-5418
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Full length human recombinant protein of human TWIST2 (NP_476527) produced in E. coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.3, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
twist homolog 2 (Drosophila)
Introduction
TWIST2 is a basic helix-loop-helix type transcription factor and shares similarity with Twist. This protein may inhibit osteoblast maturation and maintain cells in a preosteoblast phenotype during osteoblast development. This gene may be upregulated in certain cancers. Mutations in this gene cause focal facial dermal dysplasia 3, Setleis type.
Entrez Gene ID
117581
UniProt ID
Q8WVJ9
Alternative Names
Twist Family BHLH Transcription Factor 2; Twist Basic Helix-Loop-Helix Transcription Factor 2; Class A Basic Helix-Loop-Helix Protein 39; Dermis-Expressed Protein 1; BHLHa39; DERMO1; Twist-Related BHLH Protein Dermo1; Twist Homolog 2 (Drosophila)
Function
Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of pro-inflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism (By similarity).
Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors.
Biological Process
Biological Process cell differentiation Source:UniProtKB-KW
Biological Process developmental process Source:GO_Central1 Publication
Biological Process negative regulation of apoptotic process Source:Ensembl
Biological Process negative regulation of DNA-templated transcription Source:UniProtKB
Biological Process negative regulation of osteoblast differentiation Source:UniProtKB1 Publication
Biological Process positive regulation of cell migration Source:BHF-UCL1 Publication
Biological Process regulation of transcription by RNA polymerase II Source:GO_Central1 Publication
Biological Process response to insulin Source:Ensembl
Biological Process response to organic cyclic compound Source:Ensembl
Cellular Location
Nucleus
Cytoplasm
Mainly nuclear during embryonic development. Cytoplasmic in adult tissues.
Involvement in disease
Focal facial dermal dysplasia 3, Setleis type (FFDD3):
A form of focal facial dermal dysplasia, a group of developmental defects characterized by bitemporal or preauricular skin lesions resembling aplasia cutis congenita. FFDD3 is characterized by distinctive bitemporal scar-like depressions resembling forceps marks, and additional facial features, including a coarse and leonine appearance, absent eyelashes on both lids or multiple rows on the upper lids, absent Meibomian glands, slanted eyebrows, chin clefting, and hypo- or hyperpigmentation of the skin. Histologically, the bitemporal lesion is an ectodermal dysplasia with near absence of subcutaneous fat, suggesting insufficient migration of neural crest cells into the frontonasal process and the first branchial arch.
Ablepharon-macrostomia syndrome (AMS):
A congenital ectodermal dysplasia characterized by absent eyelids, macrostomia, microtia, redundant skin, sparse hair, dysmorphic nose and ears, variable abnormalities of the nipples, genitalia, fingers, and hands, largely normal intellectual and motor development, and poor growth.
Barber-Say syndrome (BBRSAY):
A rare ectodermal dysplasia characterized by ectropion, macrostomia, ear abnormalities, broad nasal bridge, bulbous nose, redundant skin, hypertrichosis, dental abnormalities, and variable other features.
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For research use only. Not intended for any clinical use.

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