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Mouse Anti-UQCRC2 Recombinant Antibody (13G12AF12BB11) (CBMAB-C1043-CN)

This product is a Mouse antibody that recognizes UQCRC2. The antibody 13G12AF12BB11 can be used for immunoassay techniques such as: IF.
See all UQCRC2 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse
Clone
13G12AF12BB11
Antibody Isotype
IgG1
Application
IF

Basic Information

Immunogen
Tissue, cells or virus corresponding to Cow UQCRC2.
Specificity
Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
Ubiquinol-Cytochrome C Reductase Core Protein 2
Introduction
The protein encoded by this gene is located in the mitochondrion, where it is part of the ubiquinol-cytochrome c reductase complex (also known as complex III). This complex constitutes a part of the mitochondrial respiratory chain. Defects in this gene are a cause of mitochondrial complex III deficiency nuclear type 5. [provided by RefSeq, Jul 2015]
Entrez Gene ID
67003
UniProt ID
Q9DB77
Alternative Names
Ubiquinol-Cytochrome C Reductase Core Protein 2; Ubiquinol-Cytochrome-C Reductase Complex Core Protein 2; Ubiquinol-Cytochrome C Reductase Core Protein II; Complex III Subunit 2; Cytochrome B-C1 Complex Subunit 2, Mitochondrial; Cytochrome Bc-1 Complex Core Protein II;
Function
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (By similarity).
The 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2 are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively, and they seem to have preserved their MPP processing properties (By similarity).
May be involved in the in situ processing of UQCRFS1 into the mature Rieske protein and its mitochondrial targeting sequence (MTS)/subunit 9 when incorporated into complex III (Probable).
Biological Process
Biological Process aerobic respiration Source:ProtInc1 Publication
Biological Process cellular respiration Source:ComplexPortal1 Publication
Biological Process mitochondrial electron transport, ubiquinol to cytochrome c Source:ComplexPortal1 Publication
Biological Process oxidative phosphorylation Source:ProtInc1 Publication
Biological Process proteolysis Source:InterPro
Cellular Location
Mitochondrion inner membrane
Involvement in disease
Mitochondrial complex III deficiency, nuclear 5 (MC3DN5):
A disorder of the mitochondrial respiratory chain resulting in a highly variable phenotype depending on which tissues are affected. Clinical features include mitochondrial encephalopathy, psychomotor retardation, ataxia, severe failure to thrive, liver dysfunction, renal tubulopathy, muscle weakness and exercise intolerance.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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